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AB144424

CAY10575, IKK-epsilon inhibitor

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MW 487.6 Da, Purity >95%. IKK-ε inhibitor (IC50 = 15.8 μM). Benzimidazole (ab143577) derivative.

View Alternative Names

Cell cycle regulated protein kinase, PLK, PLK1_HUMAN, Polo-like kinase 1, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1

Key facts

CAS number

916985-21-2

Purity

>95%

Molecular weight

487.6 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>1</sub>N<sub>3</sub>O<sub>6</sub>S<sub>2</sub>

PubChem

25190912

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide

Biological description

IKK-ε inhibitor (IC50 = 15.8 μM). Benzimidazole (ab143577) derivative.

Canonical smiles

COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=C(C=C4)S(=O)(=O)C)OC

InChi

InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)

InChiKey

YYZTVTZCYVZGRB-UHFFFAOYSA-N

IUPAC Name

5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB145522

TPCA 1, IkappaB kinase inhibitor

Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

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Biochemicals

AB142825

Amlexanox, TBK1 and IKKepsilon inhibitor

Chemical Structure - Amlexanox, TBK1 and IKKepsilon inhibitor (AB142825)

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Proteins & Peptides

AB51426

Recombinant human PLK1 protein

Functional Studies - Recombinant human PLK1 protein (AB51426)

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Primary Antibodies

AB17056

Anti-PLK1 antibody [35-206]

Trial Size

Immunocytochemistry - Anti-PLK1 antibody [35-206] (AB17056)

  • 4
  • 6

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