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AB120903

CAY10626, PI3Kalpha/mTOR inhibitor

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MW 624.66 g/mol, Purity >98%. Potent, dual PI3Kα/mTOR inhibitor (IC50 values are 0.9 and 0.6 nM at PI3Kα and mTOR, respectively). Inhibits tumor cell growth, suppresses phosphorylation of downstream targets of PI3Kα and mTOR in vitro and promotes tumor regression in vivo..
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Functional Studies - CAY10626, PI3Kalpha/mTOR inhibitor (AB120903)
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Functional Studies - CAY10626, PI3Kalpha/mTOR inhibitor (AB120903)

ab81283 staining AKT1 (phospho S473) in PC3 cells treated with CAY10626 (ab120903), by ICC/IF. Decrease of AKT1 (phospho S473) expression correlates with increased concentration of CAY10626, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120903 (CAY10626) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab81283 (1/100) dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - CAY10626, PI3Kalpha/mTOR inhibitor (AB120903)
  • Chemical Structure

Lab

Chemical Structure - CAY10626, PI3Kalpha/mTOR inhibitor (AB120903)

2D chemical structure image of ab120903, CAY10626, PI3Kalpha/mTOR inhibitor

Key facts

CAS number

1202884-94-3

Purity

>98%

Molecular weight

624.66 g/mol

Molecular formula

C<sub>3</sub><sub>1</sub>H<sub>3</sub><sub>5</sub>F<sub>3</sub>N<sub>8</sub>O<sub>3</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biological description

Potent, dual PI3Kα/mTOR inhibitor (IC50 values are 0.9 and 0.6 nM at PI3Kα and mTOR, respectively). Inhibits tumor cell growth, suppresses phosphorylation of downstream targets of PI3Kα and mTOR in vitro and promotes tumor regression in vivo.

Canonical smiles

O=C(NC1=CC=C(C(N(C)CCN(C)C)=O)C=C1)NC2=CC=C(C3=NC(N4CCOCC4)=C(C=CN5CC(F)(F)F)C5=N3)C=C2

IUPAC Name

N-[2-(Dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]benzamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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