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AB285388

CB-1158 (Numidargistat)

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MW 287.12 Da, Purity >97%. Potent, selective inhibitor of human arginase I (IC₅₀ = 98 nM), an immune-mediated anti-tumor agent. Displays potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, etc.

View Alternative Names

A I, ARG 1, ARGI1_HUMAN, Al, Arginase liver, Arginase type I, Arginase-1, Liver-type arginase, Type I arginase

Key facts

CAS number

2095732-06-0

Purity

>97%

Form

Solid

form

Molecular weight

287.12 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>2</sub><sub>2</sub>BN<sub>3</sub>O<sub>5</sub>

PubChem

131801114

Nature

Synthetic

Solubility

DMSO

Biochemical name

Numidargistat

Biological description

Potent, selective inhibitor of human arginase I (IC₅₀ = 98 nM), an immune-mediated anti-tumor agent. Displays potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, etc.

Canonical smiles

B(CCCC1CN(CC1(C(=O)O)N)C(=O)C(C)N)(O)O

Isomeric smiles

B(CCC[C@H]1CN(C[C@]1(C(=O)O)N)C(=O)[C@H](C)N)(O)O

InChi

InChI=1S/C11H22BN3O5/c1-7(13)9(16)15-5-8(3-2-4-12(19)20)11(14,6-15)10(17)18/h7-8,19-20H,2-6,13-14H2,1H3,(H,17,18)/t7-,8-,11-/m0/s1

InChiKey

ZZJLMZYUGLJBSO-LAEOZQHASA-N

IUPAC Name

(3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid

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Complementary Products

Multiplex Kits

AB201111

Protease Inhibitor Cocktail (EDTA-free)

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  • 1
Biochemicals

AB145343

5(6)-Aminofluorescein (mixture of isomers), Fluorescein derivative

Chemical Structure - 5(6)-Aminofluorescein (mixture of isomers), Fluorescein derivative (AB145343)

  • 0
  • 0
Multiplex Kits

AB201112

Phosphatase Inhibitor Cocktail I

  • 0
  • 0
Biochemicals

AB120130

(R,S)-AMPA, AMPA agonist

Functional Studies - (R,S)-AMPA, AMPA agonist (AB120130)

  • 0
  • 0
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2228 CB-1158. B2228-5 is the same size as the 5 mg size of ab285388.

Protect from air and light.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Toxic, refer to SDS for further information.

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Product protocols

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Product promise

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