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AB146412

CCT 018159, Hsp90 ATPase inhibitor

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(3 Publications)

MW 352.39 g/mol, Purity >98%. Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression.
1 Images
Chemical Structure - CCT 018159, Hsp90 ATPase inhibitor (AB146412)
  • Chemical Structure

Lab

Chemical Structure - CCT 018159, Hsp90 ATPase inhibitor (AB146412)

2D chemical structure image of ab146412, CCT 018159, Hsp90 ATPase inhibitor

Key facts

CAS number

171009-07-7

Purity

>98%

Form

Solid

form

Molecular weight

352.39 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biological description

Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

Canonical smiles

CCC1CC(C(CC1O)O)C2C(C([NH]N2)C)C3CCC4C(C3)OCCO4

InChi

InChI=1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22)

InChiKey

OWPMENVYXDJDOW-UHFFFAOYSA-N

IUPAC Name

4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Current topics in medicinal chemistry 15:57-64 PubMed25579569

2015

Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target.

Applications

Unspecified application

Species

Unspecified reactive species

Nageswara Rao Dunna,Srinivas Bandaru,Uday Raj Akare,Siddheshwar Rajadhyax,Venkata Ravi Gutlapalli,Mukesh Yadav,Anuraj Nayarisseri

Oncotarget 1:185-97 PubMed21037799

2010

Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Mounia Beloueche-Babari,Vaitha Arunan,L Elizabeth Jackson,Nina Perusinghe,Swee Y Sharp,Paul Workman,Martin O Leach

Cancer research 67:2206-16 PubMed17332351

2007

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Swee Y Sharp,Kathy Boxall,Martin Rowlands,Chrisostomos Prodromou,S Mark Roe,Alison Maloney,Marissa Powers,Paul A Clarke,Gary Box,Sharon Sanderson,Lisa Patterson,Thomas P Matthews,Kwai-Ming J Cheung,Karen Ball,Angela Hayes,Florence Raynaud,Richard Marais,Laurence Pearl,Sue Eccles,Wynne Aherne,Edward McDonald,Paul Workman
View all publications
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