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AB141305

CD 437, RARgamma-selective agonist.

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(1 Publication)

MW 398.5 Da, Purity >99%. Potent, cell-permeable RARγ-selective agonist (EC50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -independent effects on differentiation and apoptosis. Shows antitumor effects in vivo..
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Chemical Structure - CD 437, RARgamma-selective agonist. (AB141305)
  • Chemical Structure

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Chemical Structure - CD 437, RARgamma-selective agonist. (AB141305)

2D chemical structure image of ab141305, CD 437, RARgamma-selective agonist.

Key facts

CAS number

125316-60-1

Purity

>99%

Form

Solid

form

Molecular weight

398.5 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>2</sub><sub>6</sub>O<sub>3</sub>

PubChem

135411

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 10 mM

Biochemical name

6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid

Biological description

Potent, cell-permeable RARγ-selective agonist (EC50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -independent effects on differentiation and apoptosis. Shows antitumor effects in vivo.

Canonical smiles

C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O

InChi

InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChiKey

LDGIHZJOIQSHPB-UHFFFAOYSA-N

IUPAC Name

6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neuropharmacology 163:107657 PubMed31170403

2019

Retinoic acid receptor gamma is targeted by microRNA-124 and inhibits neurite outgrowth.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohong Su,Xi Gu,Zhiduo Zhang,Weipeng Li,Xuemin Wang
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