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AB141560

CDC, lipoxygenase inhibitor

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(1 Publication)

MW 321.3 g/mol, Purity >98%. Potent, selective 12-Lipoxygenase (12-LO) inhibitor (IC50 = 63 nM). Also inhibits 15-LO and 5-LO (IC50 values are 3.33 and 1.89 μM respectively). Active in vivo.
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Chemical Structure - CDC, lipoxygenase inhibitor (AB141560)
  • Chemical Structure

Lab

Chemical Structure - CDC, lipoxygenase inhibitor (AB141560)

2D chemical structure image of ab141560, CDC, lipoxygenase inhibitor

Key facts

CAS number

132465-11-3

Purity

>98%

Form

Solid

form

Molecular weight

321.3 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>5</sub>NO<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 10 mM

Biological description

Potent, selective 12-Lipoxygenase (12-LO) inhibitor (IC50 = 63 nM). Also inhibits 15-LO and 5-LO (IC50 values are 3.33 and 1.89 μM respectively). Active in vivo.

Isomeric smiles

N#C\C(=C\C1CC(O)C(O)CC1)C(=O)OC\C=C\C2CCCCC2

InChi

InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11-

InChiKey

XGHYFEJMJXGPGN-CHLGNXTCSA-N

IUPAC Name

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 10:633 PubMed30733433

2019

Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A.

Applications

Unspecified application

Species

Unspecified reactive species

Andreas Körner,Martin Schlegel,Torsten Kaussen,Verena Gudernatsch,Georg Hansmann,Timo Schumacher,Martin Giera,Valbona Mirakaj
View all publications

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