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MW 364.4 Da, Purity >98%. Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic *in vivo*.

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Images

Chemical Structure - CDPPB, positive allosteric modulator for mGlu5 (AB120363), expandable thumbnail

Key facts

CAS number
781652-57-1
Purity
> 98%
Form
Solid
Molecular weight
364.4 Da
Molecular formula
C23H16N4O
PubChem identifier
11245456
Nature
Synthetic

Target data

Alternative names

GLUR, GPRC1E, GRM5_HUMAN, Glutamate receptor metabotropic 5, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, PPP1R86, Protein phosphatase 1 regulatory subunit 86, Smp_128940, mGlu5, mGluR5

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MW 364.4 Da, Purity >98%. Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic *in vivo*.

Key facts

Purity
> 98%
PubChem identifier
11245456
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Cdppb
Biological description

Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic *in vivo*.

Canonical SMILES
C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
InChI
InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
InChIKey
BKUIZWILNWHFHD-UHFFFAOYSA-N
IUPAC name
3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - CDPPB, positive allosteric modulator for mGlu5 (ab120363), expandable thumbnail

    Chemical Structure - CDPPB, positive allosteric modulator for mGlu5 (ab120363)

    2D chemical structure image of ab120363, CDPPB, positive allosteric modulator for mGlu5

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Product protocols

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