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AB120363

CDPPB, positive allosteric modulator for mGlu5

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MW 364.4 Da, Purity >98%. Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic *in vivo*.
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Chemical Structure - CDPPB, positive allosteric modulator for mGlu5 (AB120363)
  • Chemical Structure

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Chemical Structure - CDPPB, positive allosteric modulator for mGlu5 (AB120363)

2D chemical structure image of ab120363, CDPPB, positive allosteric modulator for mGlu5

Key facts

CAS number

781652-57-1

Purity

>98%

Form

Solid

form

Molecular weight

364.4 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>1</sub><sub>6</sub>N<sub>4</sub>O

PubChem

11245456

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Cdppb

Biological description

Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic *in vivo*.

Canonical smiles

C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4

InChi

InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)

InChiKey

BKUIZWILNWHFHD-UHFFFAOYSA-N

IUPAC Name

3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide

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Biochemicals

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Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB76316

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] (AB76316)

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Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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