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MW 355.7 Da, Purity >98%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).

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Images

Chemical Structure - Ceefourin™ 2, MRP4 inhibitor (AB145145), expandable thumbnail

Key facts

CAS number
348148-51-6
Purity
> 98%
Form
Solid
Molecular weight
355.7 Da
Molecular formula
C15H9ClF3N3O2
PubChem identifier
1366977
Nature
Synthetic

Target data

Recommended products

MW 355.7 Da, Purity >98%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).

Key facts

Purity
> 98%
PubChem identifier
1366977
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Biological description

Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).

Canonical SMILES
CC1=CC=C(C=C1)C2=NC3=C(C(=NN3C(=C2)C(F)(F)F)C(=O)O)Cl
InChI
InChI=1S/C15H9ClF3N3O2/c1-7-2-4-8(5-3-7)9-6-10(15(17,18)19)22-13(20-9)11(16)12(21-22)14(23)24/h2-6H,1H3,(H,23,24)
InChIKey
ZGYIZPUVZOKRHH-UHFFFAOYSA-N
IUPAC name
3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.

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1 product image

  • Chemical Structure - Ceefourin™ 2, MRP4 inhibitor (ab145145), expandable thumbnail

    Chemical Structure - Ceefourin™ 2, MRP4 inhibitor (ab145145)

    2D chemical structure image of ab145145, Ceefourin™ 2, MRP4 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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