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AB145145

Ceefourin™ 2, MRP4 inhibitor

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MW 355.7 Da, Purity >98%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).
1 Images
Chemical Structure - Ceefourin™ 2, MRP4 inhibitor (AB145145)
  • Chemical Structure

Lab

Chemical Structure - Ceefourin™ 2, MRP4 inhibitor (AB145145)

2D chemical structure image of ab145145, Ceefourin™ 2, MRP4 inhibitor

Key facts

CAS number

348148-51-6

Purity

>98%

Form

Solid

form

Molecular weight

355.7 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>9</sub>ClF<sub>3</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

1366977

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Biological description

Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).

Canonical smiles

CC1=CC=C(C=C1)C2=NC3=C(C(=NN3C(=C2)C(F)(F)F)C(=O)O)Cl

InChi

InChI=1S/C15H9ClF3N3O2/c1-7-2-4-8(5-3-7)9-6-10(15(17,18)19)22-13(20-9)11(16)12(21-22)14(23)24/h2-6H,1H3,(H,23,24)

InChiKey

ZGYIZPUVZOKRHH-UHFFFAOYSA-N

IUPAC Name

3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

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Product details

Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB145144

Ceefourin™ 1, MRP4 inhibitor

Chemical Structure - Ceefourin™ 1, MRP4 inhibitor (AB145144)

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Biochemicals

AB143654

D-Luciferin, chemiluminescent luciferase substrate

Chemical Structure - D-Luciferin, chemiluminescent luciferase substrate (AB143654)

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Proteins & Peptides

AB233665

Recombinant human TLR4 protein (Active)

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Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

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