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MW 450.6 Da, Purity >99%. Anti-inflammatory and antiproliferative effects (IC50 = 2.12 μM). Able to modulate multiple cell-signaling pathways (inhibits NF-κB, upregulates cytoplasmic HSP70 and HSP27, suppress VEGF/Akt/mTOR pathways and inhibits TNF-α, proteasome inhibitor).
Alternative names=70Z-SHP, Abacavir hypersensitivity, susceptibility to, BPTP3, Beta-interferon, CMM9, DKCA2, DKCB4, Drug-induced liver injury due to flucloxacillin, EC 3.1.3.48, Fibroblast interferon, HCP, HCPH, HEST2, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, HPTP1C, HSF1_HUMAN, HSTF 1, Heat shock factor 1, Heat shock factor protein 1, Heat shock transcription factor 1, Hematopoietic cell phosphatase, Hematopoietic cell protein-tyrosine phosphatase, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JMML, Lymphocyte antigen, METCDS, MGC14433, MGC96956, MHC class I antigen B 7, Major Histocompatibility Complex Class I B, Non receptor tyrosine phosphatase 1, OTTHUMP00000166107, OTTHUMP00000166108, PFBMFT1, PTN11_HUMAN, PTN1_HUMAN, PTN6_HUMAN, PTP-1B, PTP-1C, PTP-1D, PTP-2C, PTPN 1, PTPN11, Protein phosphotyrosylphosphatase 1B, Protein tyrosine phosphatase 2, Protein tyrosine phosphatase non receptor type 1, Protein tyrosine phosphatase non receptor type 11, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase placental, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase SHP-1, Ptpn6, RGS17_HUMAN, RGSZ2, Regulator of G protein signalling 17, Regulator of G protein signalling Z2, Regulator of G-protein signaling 17, SAP-2, SH-PTP1, SH-PTP2, SH-PTP3, SH2 domain containing protein tyrosine phosphatase 2, SHP 1L, SHP-2, Synovitis, chronic, susceptibility to, TCS1, TERT_HUMAN, TP2, TRT, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2, Telomere Reverse Transcriptase, Tyrosine-protein phosphatase non-receptor type 1, Tyrosine-protein phosphatase non-receptor type 11, Tyrosine-protein phosphatase non-receptor type 6, hRGS17, hTRT, htert, leukocyte antigen class I-B
- CAS number
34157-83-0
- Purity
> 99%
- Form
Solid
- Source
Celastrus scandens
- Molecular weight
450.6 Da
- Molecular formula
C29H38O4
- PubChem identifier
122724
- Nature
Native
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MW 450.6 Da, Purity >99%. Anti-inflammatory and antiproliferative effects (IC50 = 2.12 μM). Able to modulate multiple cell-signaling pathways (inhibits NF-κB, upregulates cytoplasmic HSP70 and HSP27, suppress VEGF/Akt/mTOR pathways and inhibits TNF-α, proteasome inhibitor).
Alternative names=70Z-SHP, Abacavir hypersensitivity, susceptibility to, BPTP3, Beta-interferon, CMM9, DKCA2, DKCB4, Drug-induced liver injury due to flucloxacillin, EC 3.1.3.48, Fibroblast interferon, HCP, HCPH, HEST2, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, HPTP1C, HSF1_HUMAN, HSTF 1, Heat shock factor 1, Heat shock factor protein 1, Heat shock transcription factor 1, Hematopoietic cell phosphatase, Hematopoietic cell protein-tyrosine phosphatase, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JMML, Lymphocyte antigen, METCDS, MGC14433, MGC96956, MHC class I antigen B 7, Major Histocompatibility Complex Class I B, Non receptor tyrosine phosphatase 1, OTTHUMP00000166107, OTTHUMP00000166108, PFBMFT1, PTN11_HUMAN, PTN1_HUMAN, PTN6_HUMAN, PTP-1B, PTP-1C, PTP-1D, PTP-2C, PTPN 1, PTPN11, Protein phosphotyrosylphosphatase 1B, Protein tyrosine phosphatase 2, Protein tyrosine phosphatase non receptor type 1, Protein tyrosine phosphatase non receptor type 11, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase placental, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase SHP-1, Ptpn6, RGS17_HUMAN, RGSZ2, Regulator of G protein signalling 17, Regulator of G protein signalling Z2, Regulator of G-protein signaling 17, SAP-2, SH-PTP1, SH-PTP2, SH-PTP3, SH2 domain containing protein tyrosine phosphatase 2, SHP 1L, SHP-2, Synovitis, chronic, susceptibility to, TCS1, TERT_HUMAN, TP2, TRT, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2, Telomere Reverse Transcriptase, Tyrosine-protein phosphatase non-receptor type 1, Tyrosine-protein phosphatase non-receptor type 11, Tyrosine-protein phosphatase non-receptor type 6, hRGS17, hTRT, htert, leukocyte antigen class I-B
Key facts
- CAS number
34157-83-0
- Purity
> 99%
- Form
Solid
- Source
Celastrus scandens
- Molecular weight
450.6 Da
- Molecular formula
C29H38O4
- PubChem identifier
122724
- Nature
Native
- Biochemical name
Celastrol
- Biological description
Anti-inflammatory and antiproliferative effects (IC50 = 2.12 μM). Able to modulate multiple cell-signaling pathways (inhibits NF-κB, upregulates cytoplasmic HSP70 and HSP27, suppress VEGF/Akt/mTOR pathways and inhibits TNF-α, proteasome inhibitor).
- Canonical SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
- Isomeric SMILES
CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
- InChI
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
- InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
- IUPAC name
(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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