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AB141988

Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor

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(5 Publications)

MW 381.4 Da. Selective COX-2 inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Non-steroidal anti-inflammatory drug. Enhances tumor cell apoptosis in vivo. Orally active.
1 Images
Chemical Structure - Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor (AB141988)
  • Chemical Structure

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Chemical Structure - Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor (AB141988)

2D chemical structure image of ab141988, Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor

Key facts

CAS number

169590-42-5

Form

Solid

form

Molecular weight

381.4 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>4</sub>F<sub>3</sub>N<sub>3</sub>O<sub>2</sub>S

PubChem

2662

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Soluble in ethanol to 50 mM

Biochemical name

Celecoxib

Biological description

Selective COX-2 inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Non-steroidal anti-inflammatory drug. Enhances tumor cell apoptosis in vivo. Orally active.

Canonical smiles

CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

InChi

InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

InChiKey

RZEKVGVHFLEQIL-UHFFFAOYSA-N

IUPAC Name

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Breast cancer research and treatment 187:695-713 PubMed34041621

2021

Combinatorial targeting of microRNA-26b and microRNA-101 exerts a synergistic inhibition on cyclooxygenase-2 in brain metastatic triple-negative breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rania Harati,Aloïse Mabondzo,Abdelaziz Tlili,Ghalia Khoder,Mona Mahfood,Rifat Hamoudi

Pharmaceuticals (Basel, Switzerland) 13: PubMed32645833

2020

Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Rania Harati,Mohammad G Mohammad,Abdelaziz Tlili,Raafat A El-Awady,Rifat Hamoudi

Journal of neuroimmunology 344:577262 PubMed32450430

2020

TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Rajen Dey,Biswadev Bishayi

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 52:1517-1534 PubMed31120230

2019

Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Naji,Khodr Issa,Assaad Eid,Rabah Iratni,Ali H Eid

BMC musculoskeletal disorders 18:462 PubMed29145862

2017

L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Chen,Xianglei Wu,Jun Zhong,Dongqing Li
View all publications
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