Cerivastatin sodium, HMG-CoA reductase inhibitor

Key facts

CAS number

143201-11-0

Purity

>98%

Form

Solid

form

Molecular weight

481.5 Da

Molecular formula

C₂₆H₃₃FNNaO₅

PubChem

23663992

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

Cerivastatin sodium

Biological description

Potent HMG-CoA reductase inhibitor (K_i = 13 nM). Shows higher potency than Lovastatin (ab120614). Enantiomerically pure pyridine derivative. Reduces plasma cholesterol levels in vivo. Orally active.

Canonical smiles

CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)[O-])O)O.[Na+]

Isomeric smiles

CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)/C=C/[C@H](C[C@H](CC(=O)[O-])O)O.[Na+]

InChi

InChI=1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1

InChiKey

GPUADMRJQVPIAS-QCVDVZFFSA-M

IUPAC Name

sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate