MW 324.2 Da, Purity >99%. Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
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- Signal transduction and targeted therapy 8:222023Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKeke Wei,Huafeng Zhang,Shuaishuai Yang,Yuxiao Cui,Bingxia Zhang,Jincheng Liu,Liang Tang,Yaoyao Tan,Simin Liu,Shiqi Chen,Wu Yuan,Xiao Luo,Chen Chen,Fei Li,Junwei Liu,Jie Chen,Pingwei Xu,Jiadi Lv,Ke Tang,Yi Zhang,Jingwei Ma,Bo HuangPubMed 36658134
- Neuron 93:587-605.e72017Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmit Agarwal et. al.PubMed 28132831
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:7206-192013Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulia Parnis,Vedrana Montana,Ignacio Delgado-Martinez,Vitali Matyash,Vladimir Parpura,Helmut Kettenmann,Israel Sekler,Christiane NoltePubMed 23616530
- Pflugers Archiv : European journal of physiology 465:997-10102013Characterization of distinct single-channel properties of Ca²⁺ inward currents in mitochondria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexander I Bondarenko et. al.PubMed 23397170
- Molecular and cellular endocrinology 353:114-272011Studying mitochondrial Ca(2+) uptake - a revisit.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClaire Jean-Quartier,Alexander I Bondarenko,Muhammad Rizwan Alam,Michael Trenker,Markus Waldeck-Weiermair,Roland Malli,Wolfgang F GraierPubMed 22100614
Key facts
- CAS number
- 75450-34-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 324.2 Da
- Molecular formula
- C15H11Cl2NOS
- PubChem identifier
- 2688
- Nature
- Synthetic
Target data
Alternative names
FLJ22233, NCKX6, NCKX6_HUMAN, Na(+)/K(+)/Ca(2+)-exchange protein 6, Sodium/potassium/calcium exchanger, Sodium/potassium/calcium exchanger 6, Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6, Solute carrier family 24 member 6
Recommended products
MW 324.2 Da, Purity >99%. Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
Key facts
- CAS number
- 75450-34-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 324.2 Da
- Molecular formula
- C15H11Cl2NOS
- PubChem identifier
- 2688
- Nature
- Synthetic
- Solubility
Soluble in water to 5 mM.
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
- Biological description
Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
- Canonical SMILES
- C1C(=O)NC2=C(C=C(C=C2)Cl)C(S1)C3=CC=CC=C3Cl
- InChI
- InChI=1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
- InChIKey
- KQEPIRKXSUIUTH-UHFFFAOYSA-N
- IUPAC name
- 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC24A6 also known as the sodium/potassium/calcium exchanger 6 or NCKX6 is a membrane protein involved in the exchange of ions. This protein enables the transport of Na+ Ca2+ and K+ ions across cellular membranes. Its molecular mass is approximately 73 kDa. SLC24A6 is expressed in several tissues particularly in the brain where its function is important for maintaining ion balance within neuronal cells.
- Biological function summary
There are important roles that SLC24A6 plays in cellular homeostasis and signal transduction. As part of a complex network of ion transporters SLC24A6 aids in regulating calcium ion concentration within cells. This regulation is essential for neuronal signaling and overall cellular communication. The ability to exchange ions efficiently allows cells to respond accurately to physiological changes.
- Pathways
SLC24A6 is involved in important signaling cascades such as the calcium signaling pathway and calcineurin signaling pathway. In the calcium signaling pathway it helps modulate intracellular calcium levels which influence various cellular processes like muscle contraction and neurotransmitter release. SLC24A6 also interacts with other ion exchangers and transporters playing a role alongside proteins such as calmodulin which further affect neuronal function.
- Associated diseases and disorders
SLC24A6 has been associated with conditions like bipolar disorder and schizophrenia. Studies suggest that dysfunction in ion homeostasis due to altered SLC24A6 activity can lead to these neurological disorders. Proteins such as DISC1 implicated in multiple mental health conditions are also connected to dysregulation observed in these diseases highlighting the involvement of SLC24A6 within complex genetic and biochemical networks contributing to mental health disorders.
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Chemical Structure - CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)
2D chemical structure image of ab120012, CGP 37157, Na+-Ca2+ exchange inhibitor
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