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AB120330

CGP 52432, GABAB antagonist

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(11 Publications)

MW 384.2 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 85 nM). Soluble in 1 ml water to give specified mM/ml concentration.
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Chemical Structure - CGP 52432, GABAB antagonist (AB120330)
  • Chemical Structure

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Chemical Structure - CGP 52432, GABAB antagonist (AB120330)

2D chemical structure image of ab120330, CGP 52432, GABAB antagonist

Key facts

CAS number

139667-74-6

Purity

>99%

Form

Solid

form

Molecular weight

384.2 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>Cl<sub>2</sub>NO<sub>4</sub>P

PubChem

132252

Nature

Synthetic

Biochemical name

3-[(3,4-Dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid

Biological description

Potent, selective GABAB antagonist (IC50 = 85 nM). Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O

InChi

InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChiKey

GJZVQXWEIYRHBE-UHFFFAOYSA-N

IUPAC Name

3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed38839301

2024

Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Margherita Caputo,Daniela Ivanova,Sylvette Chasserot-Golaz,Frédéric Doussau,Anne-Marie Haeberlé,Cathy Royer,Sebahat Ozkan,Jason Ecard,Nicolas Vitale,Michael A Cousin,Petra Tóth,Stéphane Gasman,Stéphane Ory

eLife 8: PubMed31081751

2019

Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Dorgans,Valérie Demais,Yannick Bailly,Bernard Poulain,Philippe Isope,Frédéric Doussau

eLife 7: PubMed29578411

2018

Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Sooyun Kim,Yoonsub Kim,Suk-Ho Lee,Won-Kyung Ho

Cerebral cortex (New York, N.Y. : 1991) 27:903-918 PubMed28119345

2017

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Minge,Oleg Senkov,Rahul Kaushik,Michel K Herde,Olga Tikhobrazova,Andreas B Wulff,Andrey Mironov,Toin H van Kuppevelt,Arie Oosterhof,Gaga Kochlamazashvili,Alexander Dityatev,Christian Henneberger

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:11830-47 PubMed26311767

2015

Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

Applications

Unspecified application

Species

Unspecified reactive species

Vivian M Hernández,Daniel J Hegeman,Qiaoling Cui,Daniel A Kelver,Michael P Fiske,Kelly E Glajch,Jason E Pitt,Tina Y Huang,Nicholas J Justice,C Savio Chan

Journal of neurophysiology 114:1008-21 PubMed26063780

2015

Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Christian Schauer,Tong Tong,Hugues Petitjean,Thomas Blum,Sophie Peron,Oliver Mai,Frank Schmitz,Ulrich Boehm,Trese Leinders-Zufall

Journal of neurophysiology 113:2195-209 PubMed25589590

2015

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Tristan Hedrick,Jack Waters

Frontiers in cellular neuroscience 7:209 PubMed24294191

2013

Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanni Russo,Thierry R Nieus,Silvia Maggi,Stefano Taverna

Cell reports 1:225-33 PubMed22662315

2012

Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Darrin H Brager,Arvin R Akhavan,Daniel Johnston

Nature neuroscience 15:746-53 PubMed22446881

2012

Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Rogier Min,Thomas Nevian
View all publications
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