MW 384.2 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 85 nM).
Soluble in 1 ml water to give specified mM/ml concentration.
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10 Publications for All applications
- eLife 8:2019Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKevin Dorgans et. al.PubMed 31081751
- eLife 7:2018Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSooyun Kim et. al.PubMed 29578411
- Cerebral cortex (New York, N.Y. : 1991) 27:903-9182017Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel Minge,Oleg Senkov,Rahul Kaushik,Michel K Herde,Olga Tikhobrazova,Andreas B Wulff,Andrey Mironov,Toin H van Kuppevelt,Arie Oosterhof,Gaga Kochlamazashvili,Alexander Dityatev,Christian HennebergerPubMed 28119345
- The Journal of neuroscience : the official journal of the Society for Neuroscience 35:11830-472015Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVivian M Hernández,Daniel J Hegeman,Qiaoling Cui,Daniel A Kelver,Michael P Fiske,Kelly E Glajch,Jason E Pitt,Tina Y Huang,Nicholas J Justice,C Savio ChanPubMed 26311767
- Journal of neurophysiology 114:1008-212015Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChristian Schauer et. al.PubMed 26063780
- Journal of neurophysiology 113:2195-2092015Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTristan Hedrick et. al.PubMed 25589590
- Frontiers in cellular neuroscience 7:2092013Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiovanni Russo et. al.PubMed 24294191
- Cell reports 1:225-332012Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDarrin H Brager,Arvin R Akhavan,Daniel JohnstonPubMed 22662315
- Nature neuroscience 15:746-532012Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRogier Min et. al.PubMed 22446881
- The Journal of neuroscience : the official journal of the Society for Neuroscience 32:3267-802012Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAntoine M Valera,Frédéric Doussau,Bernard Poulain,Boris Barbour,Philippe IsopePubMed 22378898
Key facts
- CAS number
- 139667-74-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 384.2 Da
- Molecular formula
- C15H24Cl2NO4P
- PubChem identifier
- 132252
- Nature
- Synthetic
Target data
Recommended products
MW 384.2 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 85 nM).
Soluble in 1 ml water to give specified mM/ml concentration.
Key facts
- CAS number
- 139667-74-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 384.2 Da
- Molecular formula
- C15H24Cl2NO4P
- PubChem identifier
- 132252
- Nature
- Synthetic
- Biochemical name
- 3-[(3,4-Dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid
- Biological description
Potent, selective GABAB antagonist (IC50 = 85 nM).
Soluble in 1 ml water to give specified mM/ml concentration.- Canonical SMILES
- CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O
- InChI
- InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)
- InChIKey
- GJZVQXWEIYRHBE-UHFFFAOYSA-N
- IUPAC name
- 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - CGP 52432, GABAB antagonist (ab120330)
2D chemical structure image of ab120330, CGP 52432, GABAB antagonist
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