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AB120337

CGP 55845 hydrochloride, GABAB antagonist

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(34 Publications)

CGP 55845 hydrochloride (CAS:149184-22-5) (ab120337) is a potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). MW 438.7, Purity >98%.

- Proven performance: cited in over 30 publications
- Available in different formats to fit your experimental needs. Larger volume format available upon request.
2 Images
Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)
  • FuncS

PubMed

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.

(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.

Montalbano et al PLoS One. 2015 Oct 13;10(10):e0140369. doi: 10.1371/journal.pone.0140369. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (AB120337)
  • Chemical Structure

Lab

Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist

Key facts

CAS number

149184-22-5

Purity

>98%

Form

Solid

form

Molecular weight

438.7 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>3</sub>Cl<sub>3</sub>NO<sub>3</sub>P

PubChem

9954841

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CGP 55845 hydrochloride

Biological description

Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.

Canonical smiles

CC(C1=CC(=C(C=C1)Cl)Cl)NCC(CP(=O)(CC2=CC=CC=C2)O)O.Cl

Isomeric smiles

C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl

InChi

InChI=1S/C18H22Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1

InChiKey

PXQAIXBYWZBYKJ-LINSIKMZSA-N

IUPAC Name

benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;hydrochloride

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Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

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Biochemicals

AB120315

Picrotoxin, GABAA antagonist

Chemical Structure - Picrotoxin, GABAA antagonist (AB120315)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (34)

Recent publications for all applications. Explore the full list and refine your search

STAR protocols 5:103255 PubMed39146190

2024

Protocol for electrophysiological measurements of circadian changes in excitability in dentate granule cells from adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Linda Overstreet-Wadiche

eLife 12: PubMed37404129

2023

Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing.

Applications

Unspecified application

Species

Unspecified reactive species

Crescent L Combe,Carol M Upchurch,Carmen C Canavier,Sonia Gasparini

Cell reports 42:112039 PubMed36749664

2023

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Angela M Vincent,Angela L Hill,Lacy K Goode,Gwendalyn D King,Karen L Gamble,Jacques I Wadiche,Linda Overstreet-Wadiche

Cell reports 40:111440 PubMed36170833

2022

Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.

Applications

Unspecified application

Species

Unspecified reactive species

Kathy Z Dai,In Bae Choi,Ryan Levitt,Mariah B Blegen,Alanna R Kaplan,Aya Matsui,J Hoon Shin,Miriam E Bocarsly,Eleanor H Simpson,Christoph Kellendonk,Veronica A Alvarez,Lauren K Dobbs

iScience 25:103922 PubMed35252816

2022

Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.

Applications

Unspecified application

Species

Unspecified reactive species

Poonam Mishra,Rishikesh Narayanan

Cell reports 36:109495 PubMed34348148

2021

Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jingliang Zhang,Xiaoling Chen,Muriel Eaton,Jiaxiang Wu,Zhixiong Ma,Shirong Lai,Anthony Park,Talha S Ahmad,Zhefu Que,Ji Hea Lee,Tiange Xiao,Yuansong Li,Yujia Wang,Maria I Olivero-Acosta,James A Schaber,Krishna Jayant,Chongli Yuan,Zhuo Huang,Nadia A Lanman,William C Skarnes,Yang Yang

Cell reports 33:108338 PubMed33147470

2020

Cerebellum-Specific Deletion of the GABA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Rudolph,Chong Guo,Stan L Pashkovski,Tomas Osorno,Winthrop F Gillis,Jeremy M Krauss,Hajnalka Nyitrai,Isabella Flaquer,Mahmoud El-Rifai,Sandeep Robert Datta,Wade G Regehr

eLife 9: PubMed32496194

2020

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ramesh Chittajallu,Kurt Auville,Vivek Mahadevan,Mandy Lai,Steven Hunt,Daniela Calvigioni,Kenneth A Pelkey,Kareem A Zaghloul,Chris J McBain

Cerebral cortex (New York, N.Y. : 1991) 30:3667-3685 PubMed32080739

2020

Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Luo,Alexandre Guet-McCreight,Vincent Villette,Ruggiero Francavilla,Beatrice Marino,Simon Chamberland,Frances K Skinner,Lisa Topolnik

eLife 9: PubMed32073397

2020

Presynaptic GABA receptors functionally uncouple somatostatin interneurons from the active hippocampal network.

Applications

Unspecified application

Species

Unspecified reactive species

Sam A Booker,Harumi Harada,Claudio Elgueta,Julia Bank,Marlene Bartos,Akos Kulik,Imre Vida
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