MW 438.7 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.
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- Cell reports 42:1120392023Circadian regulation of dentate gyrus excitability mediated by G-protein signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJose Carlos Gonzalez,Haeun Lee,Angela M Vincent,Angela L Hill,Lacy K Goode,Gwendalyn D King,Karen L Gamble,Jacques I Wadiche,Linda Overstreet-WadichePubMed 36749664
- Cell reports 40:1114402022Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKathy Z Dai,In Bae Choi,Ryan Levitt,Mariah B Blegen,Alanna R Kaplan,Aya Matsui,J Hoon Shin,Miriam E Bocarsly,Eleanor H Simpson,Christoph Kellendonk,Veronica A Alvarez,Lauren K DobbsPubMed 36170833
- iScience 25:1039222022Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPoonam Mishra,Rishikesh NarayananPubMed 35252816
- Cell reports 36:1094952021Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingliang Zhang,Xiaoling Chen,Muriel Eaton,Jiaxiang Wu,Zhixiong Ma,Shirong Lai,Anthony Park,Talha S Ahmad,Zhefu Que,Ji Hea Lee,Tiange Xiao,Yuansong Li,Yujia Wang,Maria I Olivero-Acosta,James A Schaber,Krishna Jayant,Chongli Yuan,Zhuo Huang,Nadia A Lanman,William C Skarnes,Yang YangPubMed 34348148
- Cell reports 33:1083382020Cerebellum-Specific Deletion of the GABA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephanie Rudolph,Chong Guo,Stan L Pashkovski,Tomas Osorno,Winthrop F Gillis,Jeremy M Krauss,Hajnalka Nyitrai,Isabella Flaquer,Mahmoud El-Rifai,Sandeep Robert Datta,Wade G RegehrPubMed 33147470
- eLife 9:2020Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRamesh Chittajallu et. al.PubMed 32496194
- Cerebral cortex (New York, N.Y. : 1991) 30:3667-36852020Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao Luo,Alexandre Guet-McCreight,Vincent Villette,Ruggiero Francavilla,Beatrice Marino,Simon Chamberland,Frances K Skinner,Lisa TopolnikPubMed 32080739
- eLife 9:2020Presynaptic GABA receptors functionally uncouple somatostatin interneurons from the active hippocampal network.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSam A Booker,Harumi Harada,Claudio Elgueta,Julia Bank,Marlene Bartos,Akos Kulik,Imre VidaPubMed 32073397
- Neuron 106:277-290.e62020Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAsha K Lahiri et. al.PubMed 32075716
- eLife 8:2019Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJonathan H Cornford,Marion S Mercier,Marco Leite,Vincent Magloire,Michael Häusser,Dimitri M KullmannPubMed 31657720
Key facts
- CAS number
- 149184-22-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 438.7 Da
- Molecular formula
- C18H23Cl3NO3P
- PubChem identifier
- 9954841
- Nature
- Synthetic
Recommended products
MW 438.7 Da, Purity >99%. Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.
Key facts
- CAS number
- 149184-22-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 438.7 Da
- Molecular formula
- C18H23Cl3NO3P
- PubChem identifier
- 9954841
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- CGP 55845 hydrochloride
- Biological description
Potent, selective GABAB antagonist (IC50 = 5 nM). Prevents agonist binding (pKi = 8.35) and blocks GABAB responses to Baclofen (ab120325). Inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85, respectively). Stimulates glucose induced insulin secretion.
- Canonical SMILES
- CC(C1=CC(=C(C=C1)Cl)Cl)NCC(CP(=O)(CC2=CC=CC=C2)O)O.Cl
- Isomeric SMILES
- C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl
- InChI
- InChI=1S/C18H22Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1
- InChIKey
- PXQAIXBYWZBYKJ-LINSIKMZSA-N
- IUPAC name
- benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (ab120337)
2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
Montalbano et al PLoS One. 2015 Oct 13;10(10):e0140369. doi: 10.1371/journal.pone.0140369. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (ab120337)
5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.
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