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MW 244.23 Da, Purity >98%. Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).

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Images

Chemical Structure - CGP 57380, MNK inhibitor (AB120365), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - CGP 57380, MNK inhibitor (AB120365), expandable thumbnail

Publications

Key facts

CAS number

522629-08-9

Purity

> 98%

Form

Solid

Molecular weight

244.23 Da

Molecular formula

C11H9FN6

PubChem identifier

11644425

Nature

Synthetic

Alternative names

Recommended products

MW 244.23 Da, Purity >98%. Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).

Key facts

Purity

> 98%

PubChem identifier

11644425

Solubility

Soluble in DMSO to 100 mM.

Biochemical name

N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine

Biological description

Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).

Canonical SMILES

C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F

InChI

InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)

InChIKey

UQPMANVRZYYQMD-UHFFFAOYSA-N

IUPAC name

3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

The product can be stored for up to 12 months

Product promise

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2 product images

  • Chemical Structure - CGP 57380, MNK inhibitor (ab120365), expandable thumbnail

    Chemical Structure - CGP 57380, MNK inhibitor (ab120365)

    2D chemical structure image of ab120365, CGP 57380, MNK inhibitor

  • Immunocytochemistry/ Immunofluorescence - CGP 57380, MNK inhibitor (ab120365), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - CGP 57380, MNK inhibitor (ab120365)

    Anti-eIF4E (phospho S209) antibody [EP2151Y] ab76256 staining eIF4E (phospho S209) in serum starved HEK193 cells treated with CGP 57380 (ab120365), by ICC/IF. Decrease in eIF4E (phospho S209) expression correlates with increased concentration of CGP 57380, as described in literature.
    The cells were incubated at 37°C for 1h in media containing different concentrations of ab120365 (CGP 57380) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-eIF4E (phospho S209) antibody [EP2151Y] ab76256 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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Product protocols

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