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MW 244.23 Da, Purity >98%. Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).
Alternative names=AAD20, AIK2, ARK-2, AURKB_HUMAN, AurB, Aurora 1, Aurora kinase B, Aurora- and Ipl1-like midbody-associated protein 1, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, BR serine/threonine kinase 2, BR serine/threonine-protein kinase 2, BRSK2_HUMAN, Brain selective kinase 2, Brain specific serine/threonine protein kinase 2, C11orf7, CKI-delta, CKId, CSNK 1D, Casein Kinase 1 delta, Casein kinase I delta isoform, Casein kinase I isoform delta, DKFZp686O15119, DYRK3_HUMAN, DYRK5, Double stranded RNA activated protein kinase;, Dual specificity tyrosine (Y) phosphorylation regulated kinase 3, Dual specificity tyrosine-phosphorylation-regulated kinase 3, E2AK2_HUMAN, EIF2AK1, EIF2AK2, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, Eukaryotic translation initiation factor 2-alpha kinase 2, FLJ10358, G protein coupled receptor kinase 7, GAC, GAM, GLS, GLS1, GLSK_HUMAN, GPRK7, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, HCKID, HGNC:9437, IMD22, IPL1, Interferon inducible elF2 alpha kinase, Interferon-induced, double-stranded RNA-activated protein kinase, Interferon-inducible RNA-dependent protein kinase, K-glutaminase, KC1D_HUMAN, KGA, KIAA0838, L-glutamine amidohydrolase, LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LSK, Lck p56, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MAP kinase interacting kinase 1, MAP kinase interacting serine threonine kinase, MAP kinase interacting serine threonine kinase 2, MAP kinase interacting serine threonine protein kinase 2, MAP kinase interacting serine/threonine kinase 1, MAP kinase signal-integrating kinase 1, MAP kinase signal-integrating kinase 2, MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase-interacting serine/threonine-protein kinase 2, MAPK interacting kinase 2, MAPK signal integrating kinase 1, MAPK signal integrating kinase 2, MGC126524, MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1, MKNK1_HUMAN, MKNK2_HUMAN, Membrane associated protein tyrosine kinase, Mitogen activated protein kinase interacting serine threonine kinase 2, NR3B1, Nuclear receptor subfamily 3 group B member 1, Oncogene lck, P1/eIF-2A protein kinase, PEN11B, PPP1R48, PPP1R83, PRKR, Protein YT16, Protein kinase CK1 delta, Protein kinase Dyrk3, Protein kinase RNA-activated, Protein kinase SAD1B, Protein kinase interferon inducible double stranded RNA dependent, Protein phosphatase 1 regulatory subunit 48, Protein phosphatase 1 regulatory subunit 83, Proto oncogene tyrosine protein kinase LCK, Proto-oncogene Lck, Putative map kinase interacting kinase, REDK, Regulatory erythroid kinase, SAD 1, SADA, STK-1, STK12, STK29, STK5, Serine threonine protein kinase Sgk1, Serine/theronine kinase 12, Serine/threonine kinase 29, Serine/threonine protein kinase BRSK2, Serine/threonine protein kinase TIK, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A, Serine/threonine-protein kinase aurora-B, Serum glucocorticoid regulated kinase, Steroid hormone receptor ERR1, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, Tyrosine protein kinase EIF2AK2, Tyrosine-protein kinase Lck, YT 16, eIF-2A protein kinase 2, estrogen receptor related receptor alpha, hERR1, hYAK3 2, mitochondrial, p56(LSTRA) protein tyrosine kinase, p56-LCK, p68 kinase, pp58 lck
- CAS number
522629-08-9
- Purity
> 98%
- Form
Solid
- Molecular weight
244.23 Da
- Molecular formula
C11H9FN6
- PubChem identifier
11644425
- Nature
Synthetic
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MW 244.23 Da, Purity >98%. Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).
Alternative names=AAD20, AIK2, ARK-2, AURKB_HUMAN, AurB, Aurora 1, Aurora kinase B, Aurora- and Ipl1-like midbody-associated protein 1, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, BR serine/threonine kinase 2, BR serine/threonine-protein kinase 2, BRSK2_HUMAN, Brain selective kinase 2, Brain specific serine/threonine protein kinase 2, C11orf7, CKI-delta, CKId, CSNK 1D, Casein Kinase 1 delta, Casein kinase I delta isoform, Casein kinase I isoform delta, DKFZp686O15119, DYRK3_HUMAN, DYRK5, Double stranded RNA activated protein kinase;, Dual specificity tyrosine (Y) phosphorylation regulated kinase 3, Dual specificity tyrosine-phosphorylation-regulated kinase 3, E2AK2_HUMAN, EIF2AK1, EIF2AK2, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, Eukaryotic translation initiation factor 2-alpha kinase 2, FLJ10358, G protein coupled receptor kinase 7, GAC, GAM, GLS, GLS1, GLSK_HUMAN, GPRK7, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, HCKID, HGNC:9437, IMD22, IPL1, Interferon inducible elF2 alpha kinase, Interferon-induced, double-stranded RNA-activated protein kinase, Interferon-inducible RNA-dependent protein kinase, K-glutaminase, KC1D_HUMAN, KGA, KIAA0838, L-glutamine amidohydrolase, LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LSK, Lck p56, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MAP kinase interacting kinase 1, MAP kinase interacting serine threonine kinase, MAP kinase interacting serine threonine kinase 2, MAP kinase interacting serine threonine protein kinase 2, MAP kinase interacting serine/threonine kinase 1, MAP kinase signal-integrating kinase 1, MAP kinase signal-integrating kinase 2, MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase-interacting serine/threonine-protein kinase 2, MAPK interacting kinase 2, MAPK signal integrating kinase 1, MAPK signal integrating kinase 2, MGC126524, MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1, MKNK1_HUMAN, MKNK2_HUMAN, Membrane associated protein tyrosine kinase, Mitogen activated protein kinase interacting serine threonine kinase 2, NR3B1, Nuclear receptor subfamily 3 group B member 1, Oncogene lck, P1/eIF-2A protein kinase, PEN11B, PPP1R48, PPP1R83, PRKR, Protein YT16, Protein kinase CK1 delta, Protein kinase Dyrk3, Protein kinase RNA-activated, Protein kinase SAD1B, Protein kinase interferon inducible double stranded RNA dependent, Protein phosphatase 1 regulatory subunit 48, Protein phosphatase 1 regulatory subunit 83, Proto oncogene tyrosine protein kinase LCK, Proto-oncogene Lck, Putative map kinase interacting kinase, REDK, Regulatory erythroid kinase, SAD 1, SADA, STK-1, STK12, STK29, STK5, Serine threonine protein kinase Sgk1, Serine/theronine kinase 12, Serine/threonine kinase 29, Serine/threonine protein kinase BRSK2, Serine/threonine protein kinase TIK, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A, Serine/threonine-protein kinase aurora-B, Serum glucocorticoid regulated kinase, Steroid hormone receptor ERR1, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, Tyrosine protein kinase EIF2AK2, Tyrosine-protein kinase Lck, YT 16, eIF-2A protein kinase 2, estrogen receptor related receptor alpha, hERR1, hYAK3 2, mitochondrial, p56(LSTRA) protein tyrosine kinase, p56-LCK, p68 kinase, pp58 lck
Key facts
- CAS number
522629-08-9
- Purity
> 98%
- Form
Solid
- Molecular weight
244.23 Da
- Molecular formula
C11H9FN6
- PubChem identifier
11644425
- Nature
Synthetic
- Biochemical name
N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
- Biological description
Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).
- Canonical SMILES
C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F
- InChI
InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
- InChIKey
UQPMANVRZYYQMD-UHFFFAOYSA-N
- IUPAC name
3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
The product can be stored for up to 12 months
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