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AB146956

CGRP (hu, Mod Asp3 to Pra)

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(3 Publications)

MW 3770.33 g/mol, Purity >95%. Endogenous calcitonin gene related peptide agonist. Vasodilator agent. Active in vivo and in vitro.

Key facts

Purity

>95%

Form

Solid

form

Molecular weight

3770.33 g/mol

Nature

Synthetic

Solubility

Soluble in water to 1mg/ml

Biological description

Endogenous calcitonin gene related peptide agonist. Vasodilator agent. Active in vivo and in vitro.

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Product details

CGRP (hu, Mod Asp3 to Pra) ab146956 is a 37 amino acid neuroendocrine hormone that belongs to the calcitonin (CT) family. It is a vasodilator and plays an important role in neurogenic inflammation, and therefore has gained significant interest for the treatment of migraine. CGRP exerts effects through the CGRP receptor. To probe receptor binding, labelling with TAMRA azide, 5- isomer, Orange emitting fluorescent dye (ab146486), using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) to position 3 of human αCGRP, generates a potent fluorescent CGRP.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

BMC neuroscience 12:112 PubMed22074408

2011

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.

Applications

Unspecified application

Species

Unspecified reactive species

Sajedeh Eftekhari,Lars Edvinsson

CNS drugs 24:539-48 PubMed20433208

2010

Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Paul L Durham,Carrie V Vause

Headache 46 Suppl 1:S3-8 PubMed16927957

2006

Calcitonin gene-related peptide (CGRP) and migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Paul L Durham
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