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AB120453

CGS 21680, A2A agonist

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(7 Publications)

MW 536 Da, Purity >96%. Achieve your results faster with highly validated, pure and trusted compounds.
1 Images
Chemical Structure - CGS 21680, A2A agonist (AB120453)
  • Chemical Structure

Lab

Chemical Structure - CGS 21680, A2A agonist (AB120453)

2D chemical structure image of ab120453, CGS 21680, A2A agonist

Key facts

CAS number

124431-80-7

Purity

>96%

Form

Solid

form

Molecular weight

536 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>3</sub><sub>0</sub>ClN<sub>7</sub>O<sub>6</sub>

PubChem

10256643

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CGS 21680 hydrochloride

Canonical smiles

CCNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O.Cl

Isomeric smiles

CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O.Cl

InChi

InChI=1S/C23H29N7O6.ClH/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H/t16-,17+,18-,22+;/m0./s1

IUPAC Name

3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 181:3779-3795 PubMed38877785

2024

An agonist of the adenosine A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuqin Sun,Nan Jiang,Rui Yao,Yue Song,Zewen Li,Wei Wang,Jiangfan Chen,Wei Guo

Frontiers in pharmacology 13:840134 PubMed35387355

2022

Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel Soliño,Ignacio M Larrayoz,Ester María López,Manuel Rey-Funes,Mariana Bareiro,Cesar Fabián Loidl,Elena Girardi,Alfredo Martínez,Juan José López-Costa

The Tohoku journal of experimental medicine 249:275-283 PubMed31875581

2019

Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A Adenosine Receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Kenta Fujimoto,Atsushi Shioi,Yuya Miki,Yoshinori Kakutani,Tomoaki Morioka,Tetsuo Shoji,Masanori Emoto,Masaaki Inaba

Journal of leukocyte biology 105:1225-1234 PubMed30907983

2019

Adenosine from a biologic source regulates neutrophil extracellular traps (NETs).

Applications

Unspecified application

Species

Unspecified reactive species

Kai Xu,Kimberly A Cooney,Eric Y Shin,Lanfang Wang,Juline N Deppen,Sydney C Ginn,Rebecca D Levit

Theranostics 8:5713-5730 PubMed30555576

2018

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Fang Li,Shu-Hua Ouyang,Long-Fang Tu,Xi Wang,Wei-Lin Yuan,Guo-En Wang,Yan-Ping Wu,Wen-Jun Duan,Hong-Min Yu,Zhong-Ze Fang,Hiroshi Kurihara,Youwei Zhang,Rong-Rong He

Cardiovascular diabetology 16:142 PubMed29096622

2017

Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Masashi Kawamura,Michael J Paulsen,Andrew B Goldstone,Yasuhiro Shudo,Hanjay Wang,Amanda N Steele,Lyndsay M Stapleton,Bryan B Edwards,Anahita Eskandari,Vi N Truong,Kevin J Jaatinen,Arnar B Ingason,Shigeru Miyagawa,Yoshiki Sawa,Y Joseph Woo

Immunity, inflammation and disease 6:72-80 PubMed29027376

2017

Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine-induced blood brain barrier dysfunction via suppression of MLCK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Marwan Alahiri,Bianca Ulloa,Boxun Xie,Saud A Sadiq
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