MW 696.8 Da, Purity >98%. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
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- Clinical and translational medicine 11:e5452021A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenchuan Liu,Kaiqing Wu,Shaorui Gu,Wenli Wang,Shiliang Xie,Tiancheng Lu,Lei Li,Chenglai Dong,Xishi Wang,Yongxin ZhouPubMed 34586732
- The Journal of clinical investigation 131:2020Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarly M Harro,Jairo Perez-Sanz,Tara Lee Costich,Kyle K Payne,Carmen M Anadon,Ricardo A Chaurio,Subir Biswas,Gunjan Mandal,Kristen E Rigolizzo,Kimberly B Sprenger,Jessica A Mine,Louise C Showe,Xiaoqing Yu,Kebin Liu,Paulo C Rodriguez,Javier Pinilla-Ibarz,Lubomir Sokol,Jose R Conejo-GarciaPubMed 33270606
- Oncology reports 38:693-7022017Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNakako Izumi Nakajima,Atsuko Niimi,Mayu Isono,Takahiro Oike,Hiro Sato,Takashi Nakano,Atsushi ShibataPubMed 28677817
Key facts
- CAS number
- 28097-03-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 696.8 Da
- Molecular formula
- C30H28N6O6S4
- PubChem identifier
- 161591
- Nature
- Synthetic
Recommended products
MW 696.8 Da, Purity >98%. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
Key facts
- CAS number
- 28097-03-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 696.8 Da
- Molecular formula
- C30H28N6O6S4
- PubChem identifier
- 161591
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 10 mM.
- Biochemical name
- Chaetocin from Chaetomium minutum
- Biological description
Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
- Canonical SMILES
- CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
- InChI
- InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3
- InChIKey
- PZPPOCZWRGNKIR-UHFFFAOYSA-N
- IUPAC name
- 14-(hydroxymethyl)-3-[14-(hydroxymethyl)-18-methyl-13,17-dioxo-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-trien-3-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Chaetocin, histone lysine methyltransferase inhibitor (ab144534)
2D chemical structure image of ab144534, Chaetocin, histone lysine methyltransferase inhibitor
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