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MW 326.5 Da, Purity >98%. Potent, selective, competitive farnesyltransferase inhibitor (IC50 = 55 nM). Inhibits geranylgeranyltransferase I and II and protein prenyltransferase (IC50 values are 92, 34 and 17 μM respectively). Blocks Ha-Ras signalling. Active in vivo.

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Images

Chemical Structure - Chaetomellic acid A, farnesyltransferase inhibitor (AB141622), expandable thumbnail

Key facts

CAS number
148796-51-4
Purity
> 98%
Form
Solid
Molecular weight
326.5 Da
Molecular formula
C19H34O4
PubChem identifier
3037595
Nature
Synthetic

Target data

Alternative names

CAAX farnesyltransferase alpha subunit, CAAX farnesyltransferase subunit alpha, CAAX farnesyltransferase subunit beta, EC 2.5.1.58, EC 2.5.1.59, EC=2.5.1.58, FNTA_HUMAN, FNTB_HUMAN, FPTA, FPTB, FTase-alpha, FTase-beta, Farnesyl protein transferase alpha subunit, Farnesyltransferase, Farnesyltransferase CAAX box alpha, GGTase-I-alpha, MGC105303, MGC99680, OTTHUMP00000229206, OTTHUMP00000229262, PGGT1A, PTAR2, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein prenyltransferase alpha subunit repeat containing 2, RAS proteins prenyltransferase beta, Ras proteins prenyltransferase alpha, Ras proteins prenyltransferase subunit alpha, Ras proteins prenyltransferase subunit beta, Type I protein geranyl geranyltransferase alpha subunit, Type I protein geranyl-geranyltransferase subunit alpha, farnesyltransferase CAAX box beta1, farnesyltransferase, CAAX box, beta

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MW 326.5 Da, Purity >98%. Potent, selective, competitive farnesyltransferase inhibitor (IC50 = 55 nM). Inhibits geranylgeranyltransferase I and II and protein prenyltransferase (IC50 values are 92, 34 and 17 μM respectively). Blocks Ha-Ras signalling. Active in vivo.

Key facts

Purity
> 98%
PubChem identifier
3037595
Biochemical name
Chaetomellic acid A
Biological description

Potent, selective, competitive farnesyltransferase inhibitor (IC50 = 55 nM). Inhibits geranylgeranyltransferase I and II and protein prenyltransferase (IC50 values are 92, 34 and 17 μM respectively). Blocks Ha-Ras signalling. Active in vivo.

Canonical SMILES
CCCCCCCCCCCCCCC(=C(C)C(=O)O)C(=O)O
Isomeric SMILES
CCCCCCCCCCCCCC/C(=C(\C)/C(=O)O)/C(=O)O
InChI
InChI=1S/C19H34O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19(22)23)16(2)18(20)21/h3-15H2,1-2H3,(H,20,21)(H,22,23)/b17-16-
InChIKey
ULSDRNDLXFVDED-MSUUIHNZSA-N
IUPAC name
(Z)-2-methyl-3-tetradecylbut-2-enedioic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Chaetomellic acid A, farnesyltransferase inhibitor (ab141622), expandable thumbnail

    Chemical Structure - Chaetomellic acid A, farnesyltransferase inhibitor (ab141622)

    2D chemical structure image of ab141622, Chaetomellic acid A, farnesyltransferase inhibitor

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