CHAPS, Zwitterionic non-denaturing detergent

Key facts

CAS number

75621-03-3

Purity

>98%

Form

Solid

form

Molecular weight

614.9 Da

Molecular formula

C₃₂H₅₈N₂O₇S

PubChem

107670

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Chaps

Biological description

Zwitterionic non-denaturing detergent that protects the native state of proteins, able to disrupt non-specific protein interactions and has less protein aggregation than non-ionic detergents. It is electrically neutral and easily removed by dialysis. Often used in the solubilization and purification of membrane proteins.

Canonical smiles

CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C

Isomeric smiles

C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C

InChi

InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

InChiKey

UMCMPZBLKLEWAF-BCTGSCMUSA-N

IUPAC Name

3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate