MW 710.9 Da, Purity >98%. Potent HIF signaling inhibitor. Reduces CA9 and VEGF expression in hypoxic cells (IC50 = 10 nM, secreted VEGF, Hep38 cells). Shows antibacterial and antifungal effects. Shows antitumor effects in vivo. .
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- Frontiers in cellular and infection microbiology 7:232017Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, .Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlejandro Cabezas-Cruz et. al.PubMed 28229048
Key facts
- CAS number
- 1403-36-7
- Purity
- > 98%
- Form
- Solid
- Source
- Chaetomium sp.
- Molecular weight
- 710.9 Da
- Molecular formula
- C31H30N6O6S4
- PubChem identifier
- 10417379
- Nature
- Native
Target data
Alternative names
H3-K9-HMTase 1, Histone H3-K9 methyltransferase1, Histone lysine N methyltransferase, H3 lysine 9 specific 1, Histone-lysine N-methyltransferase SUV39H1, KMT1 A, Lysine N-methyltransferase 1A, MG44, Position-effect variegation 3-9 homolog, SUV39 H1, SUV39H, SUV91_HUMAN, Su(var)3-9 homolog 1, Suppressor of variegation 3 9 homolog 1 (Drosophila), Suppressor of variegation 3-9 homolog 1, mIS6
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MW 710.9 Da, Purity >98%. Potent HIF signaling inhibitor. Reduces CA9 and VEGF expression in hypoxic cells (IC50 = 10 nM, secreted VEGF, Hep38 cells). Shows antibacterial and antifungal effects. Shows antitumor effects in vivo. .
Key facts
- CAS number
- 1403-36-7
- Purity
- > 98%
- Form
- Solid
- Source
- Chaetomium sp.
- Molecular weight
- 710.9 Da
- Molecular formula
- C31H30N6O6S4
- PubChem identifier
- 10417379
- Nature
- Native
- Solubility
Soluble in DMSO.
- Biochemical name
- Chetomin
- Biological description
Potent HIF signaling inhibitor. Reduces CA9 and VEGF expression in hypoxic cells (IC50 = 10 nM, secreted VEGF, Hep38 cells). Shows antibacterial and antifungal effects. Shows antitumor effects in vivo.
- Canonical SMILES
- CN1C(=O)C2(N(C(=O)C1(SS2)CC3=CN(C4=CC=CC=C43)C56CC78C(=O)N(C(C(=O)N7C5NC9=CC=CC=C69)(SS8)CO)C)C)CO
- Isomeric SMILES
- CN1C(=O)[C@]2(N(C(=O)[C@@]1(SS2)CC3=CN(C4=CC=CC=C43)[C@]56C[C@]78C(=O)N([C@](C(=O)N7[C@H]5NC9=CC=CC=C69)(SS8)CO)C)C)CO
- InChI
- InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1
- InChIKey
- ZRZWBWPDBOVIGQ-YWZWRZHGSA-N
- IUPAC name
- (1S,3S,11R,14S)-14-(hydroxymethyl)-3-[3-[[(1S,4S)-4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]octan-1-yl]methyl]indol-1-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
KMT1A also known as SUV39H1 is a well-studied histone methyltransferase responsible for trimethylating histone H3 at lysine 9 (H3K9me3) an important marker for heterochromatin formation. This enzyme plays a critical role in chromatin organization and gene regulation. KMT1A has a molecular weight of approximately 48 kDa. Researchers have observed its expression across a range of tissues including the brain heart and muscle which suggests its importance in various physiological processes.
- Biological function summary
KMT1A functions as part of a Suv39H1/HP1 complex that maintains the integrity of pericentric heterochromatin essential for chromosome stability during cell division. Its influence extends over the transcriptional silencing of specific genes by modifying chromatin structure to a closed state. KMT1A also collaborates with other proteins like HP1 to silence repetitive elements and prevent genomic instability which is often important for safeguarding genomic fidelity in cells.
- Pathways
Researchers identify KMT1A as a significant player in the regulation of epigenetic pathways particularly the histone methylation process. It interacts closely with other histone methyltransferases and demethylases contributing to a dynamic epigenetic landscape that controls gene expression. Additionally KMT1A is involved in the DNA damage response pathway in collaboration with proteins like ATM which coordinates repair mechanisms to maintain genetic stability and respond to cellular stress.
- Associated diseases and disorders
Researchers have linked KMT1A with cancer and neurodegenerative diseases such as Huntington’s disease. Abnormal expression or function of KMT1A can lead to disrupted heterochromatin structure and uncontrolled gene expression which contributes to tumorigenesis. Furthermore in the context of neurodegenerative conditions interactions with proteins such as HTT can exacerbate neuronal damage and cell death. Studying these associations provides insights into potential therapeutic targets for managing such diseases.
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Chemical Structure - Chetomin, HIF signaling inhibitor (ab144222)
2D chemical structure image of ab144222, Chetomin, HIF signaling inhibitor
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