JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB273615

CHIR-124

Be the first to review this product! Submit a review

|

(0 Publication)

MW 419.9 Da, Purity >98%. Novel and potent Chk1 inhibitor (IC50 = 0.3 nM), 2,000-fold more potent than Chk2 (IC50 = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC50 = 5.8 nM), PDGFR (IC50 = 6.6 nM), GSK-3 (IC50 = 23.3 nM) and Fyn (IC50 = 98.8 nM).
1 Images
Chemical Structure - CHIR-124 (AB273615)
  • Chemical Structure

Lab

Chemical Structure - CHIR-124 (AB273615)

Chemical structure of CHIR-124, 405168-58-3

Key facts

CAS number

405168-58-3

Purity

>98%

Form

Solid

form

Molecular weight

419.9 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>2</sub>ClN<sub>5</sub>O

PubChem

135399748

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one

Biological description

Novel and potent Chk1 inhibitor (IC50 = 0.3 nM), 2,000-fold more potent than Chk2 (IC50 = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC50 = 5.8 nM), PDGFR (IC50 = 6.6 nM), GSK-3 (IC50 = 23.3 nM) and Fyn (IC50 = 98.8 nM) .

Canonical smiles

C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

Isomeric smiles

C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

InChi

InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1

InChiKey

MOVBBVMDHIRCTG-LJQANCHMSA-N

IUPAC Name

4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one

style
left-column

Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB124762

Anti-p63 antibody [EPR5701]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p63 antibody [EPR5701] (AB124762)

  • 4
  • 12
Assay Kits

AB275899

Human Carbonic Anhydrase 6 (CA6) ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Carbonic Anhydrase 6 (CA6) ELISA Kit (AB275899)

  • 0
  • 0
Primary Antibodies

AB197896

Anti-S100A4 antibody [EPR14639(2)]

RabMAb|Recombinant|KO Validated

Western blot - Anti-S100A4 antibody [EPR14639(2)] (AB197896)

  • 4
  • 8

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com