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MW 465.3 Da, Purity >=95%. Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.
Alternative names=1,8-cineole 2-exo-monooxygenase, AI327312, Albendazole monooxygenase, Albendazole sulfoxidase, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CDC28A, CDK1_HUMAN, CDKN1, CELL CYCLE CONTROLLER CDC2, CP33, CP34, CP3A4_HUMAN, CYCB3, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Catabolin, Cdc 2, Cell Divsion Cycle 2 Protein, Cell cycle regulated protein kinase, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division protein kinase 1, CycB2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686D0638, DKFZp686L20222, ERK-2, ERT1, Extracellular signal-regulated kinase 2, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 alpha, GSK-3 beta, GSK3A_HUMAN, GSK3B_HUMAN, GSK3beta isoform, Glucocorticoid inducible P450, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, H1, HLP, HPK 38, HsT17299, IFN beta inducing factor, IL 1, IL-1 beta, IL1B_HUMAN, IL1F2, Interleukin 1 beta precursor, Interleukin-1 beta, KIAA0175, Likely ortholog of maternal embryonic leucine zipper kinase, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MELK_HUMAN, MGC108931, MGC111195, MGC126680, MGC140694, MK01_HUMAN, MPK38, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, NF 25, Nifedipine oxidase, OAF, OTTHUMP00000021377, OTTHUMP00000046113, OTTHUMP00000162031, Osteoclast activating factor, P34CDC2, P38, P41, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PLK, PLK1_HUMAN, PRKM 2, PRKM1, Polo-like kinase 1, Preinterleukin 1 beta, Preinterleukin beta, Pro interleukin 1 beta, Protein kinase Eg3, Protein kinase PK38, Quinine 3-monooxygenase, RP23 382O11.1, STPK 13, Serine/threonine protein kinase GSK3A, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PLK1, Taurochenodeoxycholate 6-alpha-hydroxylase, Tyrosine protein kinase MELK, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, hMELK, mKIAA0175, p34 Cdk1, p34 protein kinase, p42-MAPK, pEg3 kinase, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2
- CAS number
252917-06-9
- Purity
>= 95%
- Form
Liquid
- Molecular weight
465.3 Da
- Molecular formula
C22H18Cl2N8
- PubChem identifier
9956119
- Nature
Synthetic
Recommended products
MW 465.3 Da, Purity >=95%. Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.
Alternative names=1,8-cineole 2-exo-monooxygenase, AI327312, Albendazole monooxygenase, Albendazole sulfoxidase, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CDC28A, CDK1_HUMAN, CDKN1, CELL CYCLE CONTROLLER CDC2, CP33, CP34, CP3A4_HUMAN, CYCB3, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Catabolin, Cdc 2, Cell Divsion Cycle 2 Protein, Cell cycle regulated protein kinase, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division protein kinase 1, CycB2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686D0638, DKFZp686L20222, ERK-2, ERT1, Extracellular signal-regulated kinase 2, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 alpha, GSK-3 beta, GSK3A_HUMAN, GSK3B_HUMAN, GSK3beta isoform, Glucocorticoid inducible P450, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, H1, HLP, HPK 38, HsT17299, IFN beta inducing factor, IL 1, IL-1 beta, IL1B_HUMAN, IL1F2, Interleukin 1 beta precursor, Interleukin-1 beta, KIAA0175, Likely ortholog of maternal embryonic leucine zipper kinase, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MELK_HUMAN, MGC108931, MGC111195, MGC126680, MGC140694, MK01_HUMAN, MPK38, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, NF 25, Nifedipine oxidase, OAF, OTTHUMP00000021377, OTTHUMP00000046113, OTTHUMP00000162031, Osteoclast activating factor, P34CDC2, P38, P41, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PLK, PLK1_HUMAN, PRKM 2, PRKM1, Polo-like kinase 1, Preinterleukin 1 beta, Preinterleukin beta, Pro interleukin 1 beta, Protein kinase Eg3, Protein kinase PK38, Quinine 3-monooxygenase, RP23 382O11.1, STPK 13, Serine/threonine protein kinase GSK3A, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PLK1, Taurochenodeoxycholate 6-alpha-hydroxylase, Tyrosine protein kinase MELK, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, hMELK, mKIAA0175, p34 Cdk1, p34 protein kinase, p42-MAPK, pEg3 kinase, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2
Key facts
- CAS number
252917-06-9
- Purity
>= 95%
- Form
Liquid
- Molecular weight
465.3 Da
- Molecular formula
C22H18Cl2N8
- PubChem identifier
9956119
- Nature
Synthetic
- Biochemical name
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile
- Biological description
Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.
- Canonical SMILES
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
- InChI
InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
- InChIKey
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
- IUPAC name
6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store under desiccating conditions
Notes
CHIR99021, Sterile-Filtered ab291107, (previously known as EZSolution CHIR99021, Sterile-Filtered, 1991) is a 10 mM (4.65 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 in anhydrous DMSO.
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