CHIR99021, Sterile-Filtered (ab291107) is a potent, highly selective aminopyrimidine GSK-3 inhibitor (IC50= values are 6.7 and 10 nM at GSK-3β and GSK-3α, respectively).
- Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors
- Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization
- Already pre-dissolved to a concentration of 10 mM
View Alternative Names
1,8-cineole 2-exo-monooxygenase, AI327312, Albendazole monooxygenase, Albendazole sulfoxidase, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CDC28A, CDK1_HUMAN, CDKN1, CELL CYCLE CONTROLLER CDC2, CP33, CP34, CP3A4_HUMAN, CYCB3, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Catabolin, Cdc 2, Cell Divsion Cycle 2 Protein, Cell cycle regulated protein kinase, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division protein kinase 1, CycB2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686D0638, DKFZp686L20222, ERK-2, ERT1, Extracellular signal-regulated kinase 2, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 alpha, GSK-3 beta, GSK3A_HUMAN, GSK3B_HUMAN, GSK3beta isoform, Glucocorticoid inducible P450, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, H1, HLP, HPK 38, HsT17299, IFN beta inducing factor, IL 1, IL-1 beta, IL1B_HUMAN, IL1F2, Interleukin 1 beta precursor, Interleukin-1 beta, KIAA0175, Likely ortholog of maternal embryonic leucine zipper kinase, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MELK_HUMAN, MGC108931, MGC111195, MGC126680, MGC140694, MK01_HUMAN, MPK38, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, NF 25, Nifedipine oxidase, OAF, OTTHUMP00000021377, OTTHUMP00000046113, OTTHUMP00000162031, Osteoclast activating factor, P34CDC2, P38, P41, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PLK, PLK1_HUMAN, PRKM 2, PRKM1, Polo-like kinase 1, Preinterleukin 1 beta, Preinterleukin beta, Pro interleukin 1 beta, Protein kinase Eg3, Protein kinase PK38, Quinine 3-monooxygenase, RP23 382O11.1, STPK 13, Serine/threonine protein kinase GSK3A, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PLK1, Taurochenodeoxycholate 6-alpha-hydroxylase, Tyrosine protein kinase MELK, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, hMELK, mKIAA0175, p34 Cdk1, p34 protein kinase, p42-MAPK, pEg3 kinase, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2
Product details
The molecular weight of CHIR99021, Sterile-Filtered (ab291107) is 465.3 g/mol.
CHIR99021, Sterile-Filtered ab291107, (previously known as EZSolution CHIR99021, Sterile-Filtered, 1991) is a 10 mM (4.65 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 in anhydrous DMSO.
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
As an important regulatory protein GSK3 beta plays a role in multiple cellular functions including metabolism cell cycle and cell signaling. It often interacts with components in signaling complexes and modulates the activity of these complexes involving phosphorylation. It is involved in the regulation of transcription factors such as c-Myc and β-catenin influencing cell fate and survival. This ability to modulate diverse functions highlights GSK3 beta's importance in cellular regulation.
Pathways
GSK3 beta participates in significant signaling pathways such as the Wnt/β-catenin and insulin signaling pathways. In the Wnt pathway GSK3 beta phosphorylates β-catenin marking it for degradation which regulates gene transcription. In insulin signaling it interacts with proteins like AKT to mediate glycogen synthesis. These interactions highlight its role in maintaining cellular homeostasis and energy balance.
Complementary Products
Primary Antibodies
AB185141
Anti-GSK3 beta + GSK3 alpha antibody [EPR18814-102]
20ul selling size|RabMAb|Recombinant|KO Validated
![Western blot - Anti-GSK3 beta + GSK3 alpha antibody [EPR18814-102] (AB185141)](https://content.abcam.com/products/images/gsk3-beta-gsk3-alpha-antibody-epr18814-102-ab185141--western-blot-img8713.jpg)
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