MW 515.9 Da, Purity >98%. Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
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- iScience 27:1095102024The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnbiao Wu,Chongbin Zhong,Xudong Song,Wen Yuan,Mintian Tang,Tao Shu,Houda Huang,Pingzhen Yang,Qicai LiuPubMed 38660406
- Archives of virology 168:1472023Repurposing of artesunate, an antimalarial drug, as a potential inhibitor of hepatitis E virus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNeha Bhise,Megha Agarwal,Nidhi Thakur,P S Akshay,Sarah Cherian,Kavita LolePubMed 37115342
- The Journal of cell biology 222:2022Convergence of secretory, endosomal, and autophagic routes in trans-Golgi-associated lysosomes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLingjian Zhou,Xutong Xue,Ke Yang,Zhi Feng,Min Liu,José C Pastor-ParejaPubMed 36239631
- Frontiers in oncology 12:9116152022Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHalima Alsamri,Aysha Alneyadi,Khalid Muhammad,Mohammed Akli Ayoub,Ali Eid,Rabah IratniPubMed 35712465
- iScience 24:1028492021Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChen Xiang,Peihua Chen,Qin Zhang,Yinghui Li,Ying Pan,Wenchun Xie,Jianyuan Sun,Zhihua LiuPubMed 34381974
- Frontiers in oncology 11:6644032021Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHalima Alsamri,Hussain El Hasasna,Bincy Baby,Aysha Alneyadi,Yusra Al Dhaheri,Mohammed Akli Ayoub,Ali H Eid,Ranjit Vijayan,Rabah IratniPubMed 34055630
- Autophagy 18:142-1602021Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKarla K Frietze,Alyssa M Brown,Dividutta Das,Raymond G Franks,Jessie Lee Cunningham,Michael Hayward,Joseph T NickelsPubMed 33966599
- Nature biomedical engineering 5:815-8292021A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLonglong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Rasmus Moller,Daisy Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A Albrecht,Wen-Chun Liu,Tristan Jordan,Benjamin E Nilsson-Payant,Ilona Golynker,Justin Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Mercy Soong,Atiq Nurani,Seong Min Kim,Danni Y Zhu,Kambez H Benam,Girija Goyal,Sarah E Gilpin,Rachelle Prantil-Baun,Steven P Gygi,Rani K Powers,Kenneth E Carlson,Matthew Frieman,Benjamin R tenOever,Donald E IngberPubMed 33941899
- Frontiers in oncology 10:11382020Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKatja Eloranta,Stefano Cairo,Emmi Liljeström,Tea Soini,Antti Kyrönlahti,Jean-Gabriel Judde,David B Wilson,Markku Heikinheimo,Marjut PihlajokiPubMed 32766148
Key facts
- CAS number
- 50-63-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 515.9 Da
- Molecular formula
- C18H32ClN3O8P2
- PubChem identifier
- 64927
- Nature
- Synthetic
Alternative names
ACEE, ACES_HUMAN, ACLS, AIS, ANDR_HUMAN, AR, AR8, ARACHE, Acetylcholinesterase, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Apoptosis related acetylcholinesterase, CAR, CAR BETA, CARA, Car 1, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, DHTR, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HUMARA, HYSP1, KD, Kennedy disease (KD), MB67, MGC97144, N-ACHE, NR1I3_HUMAN, NR3C3, NR3C4, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Oncogene GLI3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, PAP A, PAPB, PGR, PPD IV, PR, PRA, PRB, PRGR_HUMAN, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, SBMA, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, YT, YT blood group, Zinc finger protein GLI 3, androgen receptor splice variant 4b, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, orphan nuclear hormone receptor
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MW 515.9 Da, Purity >98%. Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
Key facts
- CAS number
- 50-63-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 515.9 Da
- Molecular formula
- C18H32ClN3O8P2
- PubChem identifier
- 64927
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- Chloroquine phosphate
- Biological description
Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
- Canonical SMILES
- CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
- InChI
- InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
- InChIKey
- QKICWELGRMTQCR-UHFFFAOYSA-N
- IUPAC name
- 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Progesterone receptor often called PR or NR3C3 acts as a ligand-activated transcription factor. It has a molecular weight ranging from 93 to 116 kDa depending on isoforms. PR is typically expressed in reproductive tissues like uterus and mammary glands. The acetylcholinesterase enzyme (AChE) breaks down acetylcholine in neuromuscular junctions and brain synapses with a mass of about 65 kDa. Gli3 a zinc finger transcription factor weighing roughly 160 kDa is active mainly in the developing brain and limbs. Androgen receptor (AR) important for male sexual development weighs approximately 110 kDa and expresses mostly in male reproductive organs. Constitutive androstane receptor (CAR) a nuclear receptor with about 40 – 50 kDa expresses significantly in liver and intestine.
- Biological function summary
These proteins engage in distinct yet sometimes overlapping roles. PR regulates expression of genes critical for female reproductive processes. AChE facilitates termination of synaptic transmission not existing as part of a larger protein complex. Gli3 functions in limb and central nervous system development often as part of the hedgehog signaling complex. AR modulates transcription of androgen-responsive genes playing a role in male characteristics and fertility. CAR activates detoxification pathways including metabolism of drugs and toxins in the liver.
- Pathways
These proteins integrate into various important biological processes. PR participates in steroid hormone signaling pathways interacting with estrogen receptor. AChE is central to the cholinergic neurotransmission pathway connecting with nicotinic and muscarinic receptors. Gli3 associates with sonic hedgehog (Shh) pathway influencing limb patterning and brain structure alongside other Gli family members. AR involves in growth regulation pathways frequently intersecting with insulin-like growth factor 1 (IGF-1). CAR contributes to drug metabolism pathways working in conjunction with the pregnane X receptor (PXR).
- Associated diseases and disorders
These proteins are linked to significant health concerns. PR abnormalities connect with breast cancer where estrogen receptor plays a central role. Defects in AChE relate to neuromuscular disorders like myasthenia gravis. Mutations in Gli3 may cause disorders such as Greig cephalopolysyndactyly syndrome often involving other Shh pathway proteins. Dysfunctional AR can lead to androgen insensitivity syndrome and prostate cancer with key links to genes regulating cell growth. CAR variations associate with liver diseases influencing response to drugs and environmental toxins with the PXR as a related factor.
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2 product images
Immunocytochemistry - Chloroquine diphosphate, apoptosis and autophagy inhibitor (ab142116)
Anti-SQSTM1 / p62 antibody [EPR23101-103] ab240635 staining SQSTM1 in wild-type Hap1 cells and SQSTM1 knockout Hap1 cells treated with chloroquine (ab142116, 50μM for 24 hrs). The cells were fixed with 100% methanol (5 min) then permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with Anti-SQSTM1 / p62 antibody [EPR23101-103] ab240635 at 1μg/ml concentration and Anti-alpha Tubulin antibody [DM1A] - Loading Control ab7291 (Mouse monoclonal to alpha Tubulin) at 1/1000 dilution overnight at 4°C followed by a further incubation at room temperature for 1h with a goat secondary antibody to rabbit IgG (Alexa Fluor® 488) (Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed ab150081) at 2 μg/ml (shown in green) and a goat secondary antibody to mouse IgG (Alexa Fluor® 594) (Goat Anti-Mouse IgG H&L (Alexa Fluor® 594) preadsorbed ab150120) at 2 μg/ml (shown in red). Nuclear DNA was labelled in blue with DAPI.
Image was taken with a confocal microscope (Leica-Microsystems TCS SP8).
Chemical Structure - Chloroquine diphosphate, apoptosis and autophagy inhibitor (ab142116)
2D chemical structure image of ab142116, Chloroquine diphosphate, apoptosis and autophagy inhibitor
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