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MW 269.3 Da, Purity >99%. Potent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable.
Alternative names=D10Wsu179e, DKFZp686H12203, GON 10, HD 2, HD1, HD3, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, OTTHUMP00000017046, OTTHUMP00000227077, OTTHUMP00000227078, RPD 3, RPD3-2, RPD3L1, Reduced potassium dependency yeast homolog like 1, SMAP45, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, transcriptional regulator homolog RPD3
- CAS number
112522-64-2
- Purity
> 99%
- Form
Solid
- Molecular weight
269.3 Da
- Molecular formula
C15H15N3O2
- PubChem identifier
2746
- Nature
Synthetic
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MW 269.3 Da, Purity >99%. Potent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable.
Alternative names=D10Wsu179e, DKFZp686H12203, GON 10, HD 2, HD1, HD3, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, OTTHUMP00000017046, OTTHUMP00000227077, OTTHUMP00000227078, RPD 3, RPD3-2, RPD3L1, Reduced potassium dependency yeast homolog like 1, SMAP45, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, transcriptional regulator homolog RPD3
Key facts
- CAS number
112522-64-2
- Purity
> 99%
- Form
Solid
- Molecular weight
269.3 Da
- Molecular formula
C15H15N3O2
- PubChem identifier
2746
- Nature
Synthetic
- Biochemical name
Tacedinaline
- Biological description
Potent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable.
- Canonical SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N
- InChI
InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
- InChIKey
VAZAPHZUAVEOMC-UHFFFAOYSA-N
- IUPAC name
4-acetamido-N-(2-aminophenyl)benzamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1742 CI-994. 1742-50 is the same size as the 50 mg size of ab142098.
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