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AB144544

Cilastatin Sodium, dehydrodipeptidase I inhibitor

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MW 380.4 Da, Purity >98%. Selective dehydrodipeptidase I inhibitor (Ki = 0.11 μM). Inhibits leukotriene D4 hydrolase (Ki = 0.11 μM). Potentiates the antibiotic activity of Imipenem (ab141030). Shows nephroprotective effects in vivo. Orally active.

Key facts

CAS number

81129-83-1

Purity

>98%

Form

Solid

form

Molecular weight

380.4 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>5</sub>N<sub>2</sub>NaO<sub>5</sub>S

PubChem

23663403

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in DMSO to 25 mM (with warming)

Biochemical name

Cilastatin sodium

Biological description

Selective dehydrodipeptidase I inhibitor (Ki = 0.11 μM). Inhibits leukotriene D4 hydrolase (Ki = 0.11 μM). Potentiates the antibiotic activity of Imipenem (ab141030). Shows nephroprotective effects in vivo. Orally active.

Canonical smiles

CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)[O-])C.[Na+]

Isomeric smiles

CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)[O-])C.[Na+]

InChi

InChI=1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1

InChiKey

QXPBTTUOVWMPJN-QBNHLFMHSA-M

IUPAC Name

sodium;(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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