Cilostamide, PDE3 inhibitor

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MW 342.4 Da, Purity >98%. Potent, selective PDE3 inhibitor (IC₅₀ values are 27 and 50 nM for PDE3A and PDE3B, respectively). Inhibits ADP-induced platelet aggregation (IC₅₀ = 16.8 μM). Antithrombotic effects in vivo. Orally active.

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3' 5' cyclic nucleotide phosphodiesterase, 5''-cyclic nucleotide phosphodiesterase 1A, 5''-cyclic nucleotide phosphodiesterase 1B, 5''-cyclic nucleotide phosphodiesterase 1C, 5''-cyclic phosphodiesterase, 5''-cyclic phosphodiesterase A, 5''-cyclic phosphodiesterase B, 61 kDa Cam-PDE, 63 kDa Cam-PDE, ACLS, AI847709, Adipocyte cAMP phosphodiesterase cGMP inhibited, Atherosclerosis, susceptibility to, included, BXR, CAM-PDE-1A, CGB-PDE, CGI PDE, CGI-PDE A, CGI-PDE B, CGIP1, CGIPDE1, CGMP inhibited cAMP phophodiesterase, CHNG1, CN5A, CN5N, Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase, Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B, Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A, Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C, Calcium/calmodulin-dependent 3'', Calmodulin stimulated phosphodiesterase PDE1B1, Calmodulin-dependent Phosphodiesterase, Cam-PDE 1B, Cam-PDE 1C, Cyclic GMP-inhibited phosphodiesterase A, Cyclic GMP-inhibited phosphodiesterase B, Cyclic nucleotide phosphodiesterase, DKFZp686N23123, DNA binding protein, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HDL cholesterol, augmented response of, to hormone replacement, included, HSPDE1A, HSPDE1C1A, HcGIP1, HcGIP1, rat, homolog of, Human 3'5' cyclic nucleotide Phosphodiesterase, Human cGMP inhibited cAMP phosphodiesterase mRNA, LGR 3, MGC26303, MGC75129, Myocardial infarction, susceptibility to, included, NR1I2_HUMAN, NR3A1, NR3A2, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, ONR 1, OTTHUMP00000004041, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, OTTMUSP00000010350, Oncogene GLI3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAF receptor, PAF-R, PAP A, PAPB, PAR, PAR q, PDE 5, PDE1A_HUMAN, PDE1B1, PDE1B_HUMAN, PDE1C_HUMAN, PDE3A_HUMAN, PDE3B_HUMAN, PDE5A1, PDE5A_HUMAN, PDES 1B, PPD IV, PRR, PTAFR_HUMAN, Phosphodiesterase 1A, Phosphodiesterase 1A calmodulin dependent, Phosphodiesterase 1B, Phosphodiesterase 1B calmodulin dependent, Phosphodiesterase 1C, Phosphodiesterase 1C calmodulin dependent, Phosphodiesterase 1C calmodulin dependent 70kDa, Phosphodiesterase 3A, Phosphodiesterase 3A cGMP inhibited, Phosphodiesterase 3B, Phosphodiesterase 3B cGMP inhibited, Phosphodiesterase 5A, Phosphodiesterase 5A cGMP specific, Phosphodiesterase isozyme 5, Platelet-activating factor receptor, Pregnane X receptor, Presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B, RNESTROR, RP23-470B20.1, SXR, Seven transmembrane helix receptor, Steroid and xenobiotic receptor, TSH Receptor, TSHR_HUMAN, Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, cAMP Phosphodiesterase, adipocyte, cGMP-inhibited, cAMP phosphodiesterase myocardial cGMP inhibited, cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase, cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase, cGMP binding/cGMP specific phosphodiesterase, cGMP inhibited 3 5 cyclic phosphodiesterase B, cGMP inhibited 3' 5' cyclic phosphodiesterase A, cGMP specific 3'5' cyclic phosphodiesterase, cGMP specific phosphodiesterase PDE5A2, cGMP specific phosphodiesterase type 5A, cGMP-binding cGMP-specific phosphodiesterase, cGMP-inhibited 3'', cGMP-specific 3'', hCam-1, hCam-3, hTSHR I, pregnane X nuclear receptor variant 2