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MW 219.28 Da, Purity >99%. β adrenoceptor agonist (Ki = 2.32 μM). Active in vivo.

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Chemical Structure - Cimaterol, beta adrenoceptor agonist (AB120954), expandable thumbnail

Key facts

CAS number
54239-37-1
Purity
> 99%
Form
Solid
Molecular weight
219.28 Da
Molecular formula
C12H17N3O
PubChem identifier
2755
Nature
Synthetic

Target data

Alternative names

ADRB1R, ADRB1_HUMAN, ADRB2R, ADRB2_HUMAN, ADRB3R, ADRB3_HUMAN, ADRBR, Adrenergic beta 1 receptor, Adrenergic beta 2 receptor surface, Adrenergic beta 3 receptor, Adrenoceptor beta 1, Adrenoceptor beta 2 surface, B1AR, B2AR, B3AR, BAR, BETA1AR, BETA2AR, Beta 3AR, Beta-1 adrenergic receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor, Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, Beta-3 adrenergic receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor, CHNG1, Catecholamine receptor, FLJ99960, LGR 3, MGC75129, OTTHUMP00000160386, RHR, Seven transmembrane helix receptor, TSH Receptor, TSHR_HUMAN, Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, hTSHR I

Recommended products

MW 219.28 Da, Purity >99%. β adrenoceptor agonist (Ki = 2.32 μM). Active in vivo.

Key facts

Purity
> 99%
PubChem identifier
2755
Solubility

Soluble in ethanol to 50 mM.

Soluble in DMSO to 100 mM.

Biochemical name
Cimaterol
Biological description

β adrenoceptor agonist (Ki = 2.32 μM). Active in vivo.

Canonical SMILES
CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O
InChI
InChI=1S/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3
InChIKey
BUXRLJCGHZZYNE-UHFFFAOYSA-N
IUPAC name
2-amino-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzonitrile

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The TSH receptor also known as TSH-R and the beta 1 beta 2 and beta 3 adrenergic receptors are key components of the G protein-coupled receptor family. The TSH receptor primarily interacts with thyroid-stimulating hormone to regulate thyroid function and it's expressed mainly in the thyroid gland. The adrenergic receptors including beta 1 beta 2 and beta 3 subtypes respond to catecholamines like adrenaline and noradrenaline and are widely distributed across tissues such as the heart lungs and adipose tissue. The known molecular mass of these proteins ranges around 80-100 kDa for the TSH receptor and 46-65 kDa for the beta adrenergic receptors.

Biological function summary

These receptors serve different but overlapping functions within the body's systems. TSH-R is essential for stimulating the thyroid hormone production impacting metabolism and energy use. The adrenergic receptors including those acting as beta agonists mediate cardiovascular pulmonary and metabolic responses to stress stimuli. While not directly forming a complex these receptors synergistically control cardiovascular dynamics and energy homeostasis. They interact with other proteins such as G proteins to commence their signaling cascade.

Pathways

These receptors are significant in several critical signaling episodes. TSH-R is a pivotal element in the thyroid-stimulating hormone signaling pathway influencing thyroid hormone production and release. Beta adrenergic receptors are involved in the adrenergic signaling pathway in cardiomyocytes affecting heart rate and force of contraction. They connect with proteins like Gs alpha subunits and adenylate cyclase which modulate cAMP levels thereby altering diverse cellular functions.

Associated diseases and disorders

The TSH receptor plays a role in thyroid dysfunctions such as Graves' disease an autoimmune disorder where overactivity can lead to hyperthyroidism. Beta adrenergic receptors relate to conditions like heart failure where their dysregulation affects cardiac output. Disorders in adrenergic signaling involve altered expression or function of other related proteins such as phospholamban in heart failure highlighting the complexity and significance of these receptors in disease states.

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1 product image

  • Chemical Structure - Cimaterol, beta adrenoceptor agonist (ab120954), expandable thumbnail

    Chemical Structure - Cimaterol, beta adrenoceptor agonist (ab120954)

    2D chemical structure image of ab120954, Cimaterol, beta adrenoceptor agonist

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Product protocols

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