AB254224

Cinacalcet hydrochloride

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MW 393.9 Da, Purity >99%. Ca²⁺-sensing receptor agonist that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. Decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, lowers oxidative stress and displays anti fibrotic activity. Increases sensitivity of Ca²⁺-sensing receptors to serum Ca²⁺ levels. In vivo. Decreases renal epithelial-to-mesenchymal transition (EMT) and prevents the development of renal fibrosis.

View Alternative Names

ER-beta, ESR B, ESR BETA, ESR2_HUMAN, ESTR B, Erb, Estrogen Receptor 2, Estrogen receptor 2 (ER beta), Estrogen receptor beta, Estrogen receptor beta 4, IMD42, MGC129539, NR1F3, NR3A2, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 3 group A member 2, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b

Key facts

CAS number

364782-34-3

Purity

>99%

Form

Solid

form

Molecular weight

393.9 Da

Molecular formula

C22H23ClF3N

PubChem

156418

Nature

Synthetic

Solubility

Soluble in DMSO to 100mM

Biochemical name

Cinacalcet hydrochloride

Biological description

Ca²⁺-sensing receptor agonist that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. Decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, lowers oxidative stress and displays anti fibrotic activity. Increases sensitivity of Ca²⁺-sensing receptors to serum Ca²⁺ levels. In vivo. Decreases renal epithelial-to-mesenchymal transition (EMT) and prevents the development of renal fibrosis.

Canonical smiles

CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

Isomeric smiles

C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

InChi

InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

InChiKey

QANQWUQOEJZMLL-PKLMIRHRSA-N

IUPAC Name

N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

Ambient

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) and ROR gamma also known as NR3C2 and RORG are part of the nuclear receptor family of intracellular transcription factors. ERβ has a molecular mass of approximately 59 kDa while ROR gamma's mass is about 55 kDa. ERβ primarily binds estrogen and regulates gene expression playing a role in reproductive tissues cardiovascular system and brain. ROR gamma functions as a regulatory transcription factor in numerous immune cells and affects the expression of genes related to inflammation and metabolism.

Biological function summary

These receptors mediate diverse physiological processes. Estrogen Receptor beta acts in tissues by influencing cellular proliferation and differentiation processes often forming complexes with other transcriptional regulators. ROR gamma significantly participates in thymocyte differentiation and the production of pro-inflammatory cytokines contributing to immune response modulation. These functions are critical in maintaining homeostasis and adaptive responses.

Pathways

ERβ and ROR gamma engage in distinct but intersecting signaling cascades. ERβ is involved in the estrogen signaling pathway and interacts with proteins such as coactivators and corepressors influencing processes like cell cycle regulation. ROR gamma influences the Th17 cell differentiation pathway where it cooperates with transcription factors like STAT3 to regulate immune cell differentiation. Together these pathways highlight the varied roles they play in both cellular metabolism and immunity.

Disturbances in ERβ and ROR gamma activity have implications in health. Alterations in ERβ function correlate with breast cancer development and progression where it interacts with proteins like p53. ROR gamma has been linked to autoimmune conditions such as psoriasis interacting with key inflammatory molecules including IL-17A. Research on these receptors continues to uncover their roles in pathophysiology offering insights for therapeutic interventions.

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Product protocols

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Cinacalcet hydrochloride

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

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