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AB141398

Cisplatin, antineoplastic agent

3

(1 Review)

|

(10 Publications)

MW 300.05 Da. Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.
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Chemical Structure - Cisplatin, antineoplastic agent (AB141398)
  • Chemical Structure

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Chemical Structure - Cisplatin, antineoplastic agent (AB141398)

2D chemical structure image of ab141398, Cisplatin, antineoplastic agent

Key facts

CAS number

15663-27-1

Form

Solid

form

Molecular weight

300.05 Da

Molecular formula

Cl<sub>2</sub>H<sub>6</sub>N<sub>2</sub>Pt+<sub>2</sub>

PubChem

441203

Nature

Synthetic

Solubility

Soluble in water to 5 mM (with sonication)

Soluble in 0.9% w/w NaCl to 5 mM (with sonication)

Biochemical name

cis-Diamminedichloroplatinum

Biological description

Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.

Canonical smiles

N.N.Cl[Pt+2]Cl

InChi

InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+4/p-2

InChiKey

BSJGASKRWFKGMV-UHFFFAOYSA-L

IUPAC Name

azane;dichloroplatinum(2+)

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

Publications (10)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:110975 PubMed39398243

2024

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells.

Applications

Unspecified application

Species

Unspecified reactive species

David S Lee,Angela Schrader,Jiaoxia Zou,Wee Han Ang,Mark E Warchol,Lavinia Sheets

Chemical biology & drug design 103:e14395 PubMed37973414

2023

β-elemene enhances cisplatin sensitivity of non-small cell lung cancer cells via the miR-17-5p/STAT3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Qian,Tong Wenxian,He Anbing

Molecular carcinogenesis 62:1770-1781 PubMed37589422

2023

Loss of SETD2-mediated downregulation of intracellular and exosomal miRNA-10b determines MAPK pathway activation and multidrug resistance in renal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Libin Yan,Siyue Liu,Guoliang Sun,Beichen Ding,Zhize Wang,Heng Li

International journal of bioprinting 8:528 PubMed35702333

2022

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Tröndle,Guilherme Miotto,Ludovica Rizzo,Roman Pichler,Fritz Koch,Peter Koltay,Roland Zengerle,Soeren S Lienkamp,Sabrina Kartmann,Stefan Zimmermann

Journal of cellular and molecular medicine 24:10322-10337 PubMed32720467

2020

S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Niaz Mahmood,Ani Arakelian,David Cheishvili,Moshe Szyf,Shafaat A Rabbani

Cell death & disease 10:912 PubMed31801952

2019

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel J Carter,Mateus Milani,Michael Butterworth,Ahoud Alotibi,Nicholas Harper,Govindaraju Yedida,Georgia Greaves,Aoula Al-Zebeeby,Andrea L Jorgensen,Andrew G Schache,Janet M Risk,Richard J Shaw,Terry M Jones,Joseph J Sacco,Adam Hurlstone,Gerald M Cohen,Shankar Varadarajan

Clinical cancer research : an official journal of 25:7243-7255 PubMed31506388

2019

Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment.

Applications

Unspecified application

Species

Unspecified reactive species

Ren Luo,Elke Firat,Simone Gaedicke,Elena Guffart,Tsubasa Watanabe,Gabriele Niedermann

Molecular biology of the cell 30:42-55 PubMed30379607

2018

Environmental stresses induce karyotypic instability in colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihao Tan,Yong Jie Andrew Chan,Ying Jie Karen Chua,Samuel D Rutledge,Norman Pavelka,Daniela Cimini,Giulia Rancati

Medical science monitor : international medical jo 22:818-23 PubMed26968221

2016

Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Qin,Wei Xie,Xi Yang,Ning Xia,Kunling Yang

The Journal of biological chemistry 291:4862-71 PubMed26755726

2016

Regulation of Transient Site-specific Copy Gain by MicroRNA.

Applications

Unspecified application

Species

Unspecified reactive species

Joshua C Black,Hailei Zhang,Jaegil Kim,Gad Getz,Johnathan R Whetstine
View all publications

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