MW 300.05 Da. Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.
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- Chemical biology & drug design 103:e143952023β-elemene enhances cisplatin sensitivity of non-small cell lung cancer cells via the miR-17-5p/STAT3 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTian Qian,Tong Wenxian,He AnbingPubMed 37973414
- Molecular carcinogenesis 62:1770-17812023Loss of SETD2-mediated downregulation of intracellular and exosomal miRNA-10b determines MAPK pathway activation and multidrug resistance in renal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLibin Yan,Siyue Liu,Guoliang Sun,Beichen Ding,Zhize Wang,Heng LiPubMed 37589422
- International journal of bioprinting 8:5282022Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKevin Tröndle,Guilherme Miotto,Ludovica Rizzo,Roman Pichler,Fritz Koch,Peter Koltay,Roland Zengerle,Soeren S Lienkamp,Sabrina Kartmann,Stefan ZimmermannPubMed 35702333
- Journal of cellular and molecular medicine 24:10322-103372020S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNiaz Mahmood et. al.PubMed 32720467
- Cell death & disease 10:9122019Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRachel J Carter et. al.PubMed 31801952
- Clinical cancer research : an official journal of 25:7243-72552019Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRen Luo et. al.PubMed 31506388
- Molecular biology of the cell 30:42-552018Environmental stresses induce karyotypic instability in colorectal cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhihao Tan,Yong Jie Andrew Chan,Ying Jie Karen Chua,Samuel D Rutledge,Norman Pavelka,Daniela Cimini,Giulia RancatiPubMed 30379607
- Medical science monitor : international medical jo 22:818-232016Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWen Qin et. al.PubMed 26968221
- The Journal of biological chemistry 291:4862-712016Regulation of Transient Site-specific Copy Gain by MicroRNA.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoshua C Black et. al.PubMed 26755726
Key facts
- CAS number
- 15663-27-1
- Form
- Solid
- Molecular weight
- 300.05 Da
- Molecular formula
- Cl2H6N2Pt+2
- PubChem identifier
- 441203
- Nature
- Synthetic
Recommended products
MW 300.05 Da. Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.
Key facts
- CAS number
- 15663-27-1
- Form
- Solid
- Molecular weight
- 300.05 Da
- Molecular formula
- Cl2H6N2Pt+2
- PubChem identifier
- 441203
- Nature
- Synthetic
- Solubility
Soluble in water to 5 mM (with sonication).
Soluble in 0.9% w/w NaCl to 5 mM (with sonication).
- Biochemical name
- cis-Diamminedichloroplatinum
- Biological description
Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.
- Canonical SMILES
- N.N.Cl[Pt+2]Cl
- InChI
- InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+4/p-2
- InChIKey
- BSJGASKRWFKGMV-UHFFFAOYSA-L
- IUPAC name
- azane;dichloroplatinum(2+)
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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1 product image
Chemical Structure - Cisplatin, antineoplastic agent (ab141398)
2D chemical structure image of ab141398, Cisplatin, antineoplastic agent
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