MW 405.3 Da, Purity >98%. Selective serotonin reuptake inhibitor. Antidepressant in vivo. Achieve your results faster with highly validated, pure and trusted compounds.
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- Journal of psychopharmacology (Oxford, England) 36:794-8052022Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelen M Collins,Raquel Pinacho,Dersu Ozdemir,David M Bannerman,Trevor SharpPubMed 35607713
- Cell reports 39:1107952022Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDennis A Burke,Veronica A AlvarezPubMed 35545050
- Cell 183:1986-2002.e262020Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElizabeth K Unger,Jacob P Keller,Michael Altermatt,Ruqiang Liang,Aya Matsui,Chunyang Dong,Olivia J Hon,Zi Yao,Junqing Sun,Samba Banala,Meghan E Flanigan,David A Jaffe,Samantha Hartanto,Jane Carlen,Grace O Mizuno,Phillip M Borden,Amol V Shivange,Lindsay P Cameron,Steffen Sinning,Suzanne M Underhill,David E Olson,Susan G Amara,Duncan Temple Lang,Gary Rudnick,Jonathan S Marvin,Luke D Lavis,Henry A Lester,Veronica A Alvarez,Andrew J Fisher,Jennifer A Prescher,Thomas L Kash,Vladimir Yarov-Yarovoy,Viviana Gradinaru,Loren L Looger,Lin TianPubMed 33333022
- Neuropharmacology 111:169-1792016Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKarolina Podkowa et. al.PubMed 27569995
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:7113-232014Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexis R Howerton,Alison V Roland,Tracy L BalePubMed 24849347
Key facts
- CAS number
- 59729-32-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 405.3 Da
- Molecular formula
- C20H22BrFN2O
- PubChem identifier
- 77995
- Nature
- Synthetic
Alternative names
5 HTT, 5 HTTLPR, 5 hydroxytryptamine (serotonin) transporter, 5 hydroxytryptamine transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, OCD1, SC6A4_HUMAN, SERT, SERT1, Serotonin transporter 1, Slc6a4, Sodium-dependent serotonin transporter, Solute carrier family 6 (neurotransmitter transporter) member 4, Solute carrier family 6 member 4, hSERT, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
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MW 405.3 Da, Purity >98%. Selective serotonin reuptake inhibitor. Antidepressant in vivo. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 59729-32-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 405.3 Da
- Molecular formula
- C20H22BrFN2O
- PubChem identifier
- 77995
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
Soluble in ethanol to 50 mM.
- Biochemical name
- Citalopram hydrobromide
- Biological description
Selective serotonin reuptake inhibitor. Antidepressant in vivo.
- Canonical SMILES
- CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br
- InChI
- InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
- InChIKey
- WIHMBLDNRMIGDW-UHFFFAOYSA-N
- IUPAC name
- 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;hydrobromide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The serotonin transporter (SERT) also known as 5-HTT or SLC6A4 is an important protein that facilitates the reuptake of serotonin (5-HT) from the synaptic cleft back into the presynaptic neuron. This reuptake process terminates the serotonin signaling effectively controlling its availability in the brain. SERT is approximately 620 amino acids in length with a mass of around 70 kDa. Primarily expressed in the central nervous system it is also found in peripheral tissues. Its widespread presence highlights its critical role in regulating mood and cognition via serotonin modulation.
- Biological function summary
The function of SERT impacts neurotransmitter balance significantly as it is integral to serotonin regulation. By removing serotonin from the synaptic cleft and recycling it SERT maintains neurotransmitter homeostasis. SERT is not usually part of a larger protein complex but acts independently to modulate serotonin levels. The activity of SERT affects various neurological processes contributing to mood maintenance and behavioral controls.
- Pathways
Serotonin transporter influences the serotonin signaling pathway which is important for mood regulation and cognitive functions. It works alongside other proteins like monoamine oxidase which degrades serotonin and serotonin receptors that mediate its effects. Additionally SERT is involved in the pharmacological pathways of antidepressants. Escitalopram oxalate and other selective serotonin reuptake inhibitors (SSRIs) target SERT to block the reuptake of serotonin increasing its extracellular levels and synaptic availability.
- Associated diseases and disorders
SERT has a strong association with depressive disorders and anxiety due to its role in serotonin regulation. Alterations in SERT expression or function can lead to disruptions in the serotonergic system potentially resulting in mood disorders. SSRIs like escitalopram oxalate are well-known treatments that target SERT to alleviate symptoms. Moreover mutations and polymorphisms in the SERT gene have been linked to various psychiatric conditions illustrating a genetic connection to the protein’s function.
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Chemical Structure - Citalopram, 5-HT reuptake inhibitor (ab120133)
2D chemical structure image of ab120133, Citalopram, 5-HT reuptake inhibitor
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