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AB141231

CK 666, Actin polymerization inhibitor

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(10 Publications)

MW 296.3 Da, Purity >99%. Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.
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Chemical Structure - CK 666, Actin polymerization inhibitor (AB141231)
  • Chemical Structure

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Chemical Structure - CK 666, Actin polymerization inhibitor (AB141231)

2D chemical structure image of ab141231, CK 666, Actin polymerization inhibitor

Key facts

CAS number

442633-00-3

Purity

>99%

Form

Solid

form

Molecular weight

296.3 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>7</sub>FN<sub>2</sub>O

PubChem

589075

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Biological description

Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.

Canonical smiles

CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F

InChi

InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChiKey

UXRKUKRXVWJFER-UHFFFAOYSA-N

IUPAC Name

2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

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Biochemicals

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed39791760

2025

Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jiang,Purusottam Mohapatra,Maria Rossing,Wenqian Zheng,Olga Zbodakova,Jayashree Vijay Thatte,Claus Storgaard Sørensen,Thu Han Le Phan,Cord Brakebusch

Development (Cambridge, England) 149: PubMed36469048

2022

N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Koichi Hasegawa,Takeshi K Matsui,Junpei Kondo,Ken-Ichiro Kuwako

Acta biomaterialia 155:167-181 PubMed36371004

2022

Self-assembly of mesoscale collagen architectures and applications in 3D cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Liu,Ryan Y Nguyen,Gabriela A Pizzurro,Xingjian Zhang,Xiangyu Gong,Alejandro Rossello Martinez,Michael Mak

iScience 24:102724 PubMed34337357

2021

Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyuki Noguchi,Fumi Kano,Nobuhiko Maiya,Chisako Iwamoto,Shoko Yamasaki,Yosuke Otsubo,Daiki Nakatsu,Rina Kunishige,Masayuki Murata

Cell death and differentiation 28:1849-1864 PubMed33462407

2021

Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Clare Rogerson,Duncan J Wotherspoon,Cristina Tommasi,Robert W Button,Ryan F L O'Shaughnessy

eLife 9: PubMed33135633

2020

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth Rivers,Rajeev Rai,Jonas Lötscher,Michael Hollinshead,Gasper Markelj,James Thaventhiran,Austen Worth,Alessia Cavazza,Christoph Hess,Mona Bajaj-Elliott,Adrian J Thrasher

The Journal of clinical investigation 129:5600-5614 PubMed31710310

2019

Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.

Applications

Unspecified application

Species

Unspecified reactive species

Lyra O Randzavola,Katharina Strege,Marie Juzans,Yukako Asano,Jane C Stinchcombe,Christian M Gawden-Bone,Matthew Nj Seaman,Taco W Kuijpers,Gillian M Griffiths

mBio 9: PubMed29636431

2018

Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Infections.

Applications

Unspecified application

Species

Unspecified reactive species

Aaron S Dhanda,A Wayne Vogl,Sharifah E Albraiki,Carol A Otey,Moriah R Beck,Julian A Guttman

Developmental cell 44:484-499.e6 PubMed29398621

2018

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Antonina J Kruppa,Chieko Kishi-Itakura,Thomas A Masters,Joanna E Rorbach,Guinevere L Grice,John Kendrick-Jones,James A Nathan,Michal Minczuk,Folma Buss

Scientific reports 7:8547 PubMed28819224

2017

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Samer J Hanna,Kessler McCoy-Simandle,Veronika Miskolci,Peng Guo,Michael Cammer,Louis Hodgson,Dianne Cox
View all publications
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