MW 296.3 Da, Purity >99%. Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.
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- Development (Cambridge, England) 149:2022N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKoichi Hasegawa,Takeshi K Matsui,Junpei Kondo,Ken-Ichiro KuwakoPubMed 36469048
- Acta biomaterialia 155:167-1812022Self-assembly of mesoscale collagen architectures and applications in 3D cell migration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChang Liu,Ryan Y Nguyen,Gabriela A Pizzurro,Xingjian Zhang,Xiangyu Gong,Alejandro Rossello Martinez,Michael MakPubMed 36371004
- iScience 24:1027242021Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoshiyuki Noguchi,Fumi Kano,Nobuhiko Maiya,Chisako Iwamoto,Shoko Yamasaki,Yosuke Otsubo,Daiki Nakatsu,Rina Kunishige,Masayuki MurataPubMed 34337357
- Cell death and differentiation 28:1849-18642021Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClare Rogerson,Duncan J Wotherspoon,Cristina Tommasi,Robert W Button,Ryan F L O'ShaughnessyPubMed 33462407
- eLife 9:2020Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElizabeth Rivers et. al.PubMed 33135633
- The Journal of clinical investigation 129:5600-56142019Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLyra O Randzavola,Katharina Strege,Marie Juzans,Yukako Asano,Jane C Stinchcombe,Christian M Gawden-Bone,Matthew Nj Seaman,Taco W Kuijpers,Gillian M GriffithsPubMed 31710310
- mBio 9:2018Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Infections.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAaron S Dhanda et. al.PubMed 29636431
- Developmental cell 44:484-499.e62018Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAntonina J Kruppa et. al.PubMed 29398621
- Scientific reports 7:85472017The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSamer J Hanna et. al.PubMed 28819224
Key facts
- CAS number
- 442633-00-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 296.3 Da
- Molecular formula
- C18H17FN2O
- PubChem identifier
- 589075
- Nature
- Synthetic
Recommended products
MW 296.3 Da, Purity >99%. Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.
Key facts
- CAS number
- 442633-00-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 296.3 Da
- Molecular formula
- C18H17FN2O
- PubChem identifier
- 589075
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- Biological description
Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.
- Canonical SMILES
- CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
- InChI
- InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
- InChIKey
- UXRKUKRXVWJFER-UHFFFAOYSA-N
- IUPAC name
- 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - CK 666, Actin polymerization inhibitor (ab141231)
2D chemical structure image of ab141231, CK 666, Actin polymerization inhibitor
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