CK869, Actin-related protein 2/3 (Arp2/3) complex inhibitor

Key facts

CAS number

388592-44-7

Purity

>98%

Form

Solid

form

Molecular weight

394.3 Da

Molecular formula

C₁₇H₁₆BrNO₃S

PubChem

3574452

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone

Biological description

Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC₅₀ = 11 μM) and inhibits the formation of actin filament comet tails by Listeria monocytogenes in infected SKOV3 cells (IC₅₀ = 7 μM) . Does not inhibit budding or fission yeast Arp2/3 complexes.

Canonical smiles

COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC

InChi

InChI=1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3

InChiKey

MVWNPZYLNLATCH-UHFFFAOYSA-N

IUPAC Name

2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one