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AB144605

CL-316243 disodium salt, adrenergic-beta3 receptor agonist

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(5 Publications)

MW 465.8 Da, Purity >99%. Selective adrenergic-β3 receptor agonist. Induces adipose tissue remodelling in rat. Hypoglycemic agent. Active *in vivo* and *in vitro*.
1 Images
Chemical Structure - CL-316243 disodium salt, adrenergic-beta3 receptor agonist (AB144605)
  • Chemical Structure

Lab

Chemical Structure - CL-316243 disodium salt, adrenergic-beta3 receptor agonist (AB144605)

2D chemical structure image of ab144605, CL-316243 disodium salt, adrenergic-beta3 receptor agonist

Key facts

CAS number

138908-40-4

Purity

>99%

Form

Solid

form

Molecular weight

465.8 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>8</sub>ClNNa<sub>2</sub>O<sub>7</sub>

PubChem

5312115

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate

Biological description

Selective adrenergic-β3 receptor agonist. Induces adipose tissue remodelling in rat. Hypoglycemic agent. Active *in vivo* and *in vitro*.

Canonical smiles

CC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]

Isomeric smiles

C[C@H](CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NC[C@@H](C3=CC(=CC=C3)Cl)O.[Na+].[Na+]

InChi

InChI=1S/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/q;2*+1/p-2/t11-,15+;;/m1../s1

InChiKey

FUZBPOHHSBDTJQ-CFOQQKEYSA-L

IUPAC Name

disodium;5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate

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Complementary Products

Primary Antibodies

AB94506

Anti-beta 3 Adrenergic Receptor antibody

BOND RX™ Validated

Western blot - Anti-beta 3 Adrenergic Receptor antibody (AB94506)

  • 4
  • 2
Primary Antibodies

AB268020

Anti-Fibronectin antibody [EPR23110-46]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [EPR23110-46] (AB268020)

  • 4
  • 5
Primary Antibodies

AB32042

Anti-Cleaved Caspase-3 antibody [E83-77]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Cleaved Caspase-3 antibody [E83-77] (AB32042)

  • 4
  • 28
Primary Antibodies

AB195352

Anti-METTL3 antibody [EPR18810]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry - Anti-METTL3 antibody [EPR18810] (AB195352)

  • 5
  • 8
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The beta 3 adrenergic receptor also known as beta-3 adrenoceptor or B3 adrenergic receptor is a member of the adrenergic receptor family that activates the GS protein upon binding ligands like catecholamines. This receptor approximately 408 amino acids in size has a predominant mass of around 45 kDa. It is mainly expressed in adipose tissue but also found in the gallbladder urinary bladder and the gastrointestinal tract. These receptors primarily mediate lipolysis and thermogenesis in brown adipose tissue through interaction with norepinephrine and epinephrine.
Biological function summary

The beta 3 adrenergic receptor plays an important role in energy expenditure and metabolic processes. It does not typically form part of a complex but interacts with GS proteins leading to the activation of adenylyl cyclase and consequent increase in cAMP levels. This receptor is instrumental in the regulation of lipid metabolism which aids in maintaining balance in energy store.

Pathways

The beta 3 adrenergic receptor is involved in the adrenergic signaling pathways regulating energy expenditure and thermogenesis. These pathways often work together with other adrenergic receptors such as beta 1 and beta 2 receptors. An important pathway involving the beta 3 adrenergic receptor is the cAMP-dependent pathway which influences metabolic functions and energy homeostasis in the body.

The beta 3 adrenergic receptor is associated with obesity and diabetes. Altered function or expression of this receptor can impact the body's ability to regulate energy metabolism leading to these metabolic disorders. The receptor's function has connections with insulin-like growth factor 1 (IGF1) as changes in energy metabolism affect insulin signaling and glucose homeostasis. Abnormal adrenergic receptor activity can also contribute to bladder disorders due to its expression in the urinary system.
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:398 PubMed40057615

2025

Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Irais Rivera-Alvarez,Rosa Vázquez-Lizárraga,Lucía Mendoza-Viveros,Israim Sotelo-Rivera,Tannia L Viveros-Ruiz,Jesús Morales-Maza,Lorena Orozco,Marta C Romano,Lilia G Noriega,Armando R Tovar,Lorena Aguilar-Arnal,Ivette Cruz-Bautista,Carlos Aguilar-Salinas,Ricardo Orozco-Solis

Cell reports 43:113978 PubMed38522069

2024

MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Manoj Kumar Yadav,Megumi Ishida,Natalia Gogoleva,Ching-Wei Liao,Filiani Natalia Salim,Maho Kanai,Akihiro Kuno,Takuto Hayashi,Zeynab Javanfekr Shahri,Kaushalya Kulathunga,Omar Samir,Wenxin Lyu,Olivia Olivia,Evaristus C Mbanefo,Satoru Takahashi,Michito Hamada

Molecular metabolism 81:101890 PubMed38307384

2024

Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice.

Applications

Unspecified application

Species

Unspecified reactive species

Pawanrat Tangseefa,Hong Jin,Houyu Zhang,Meng Xie,Carlos F Ibáñez

Life metabolism 2:load018 PubMed39872016

2023

Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Zhang,Jianhui Chen,Qingqing Li,Wenwen Zeng

Cell reports 42:112078 PubMed36735535

2023

Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ling-Ran Kong,Xiao-Hui Chen,Qing Sun,Kai-Yuan Zhang,Lian Xu,Liliqiang Ding,Yan-Ping Zhou,Ze-Bei Zhang,Jing-Rong Lin,Ping-Jin Gao
View all publications
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