MW 213.23 Da, Purity >95%. Potent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro.
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- The Journal of neuroscience : the official journal of the Society for Neuroscience 41:4880-48882021Memory Destabilization and Reconsolidation Dynamically Regulate the PKMζ Maintenance Mechanism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMatteo Bernabo,Josue Haubrich,Karine Gamache,Karim NaderPubMed 33888608
- Scientific reports 9:131522019CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHiroaki Kajiho et. al.PubMed 31511573
Key facts
- CAS number
- 154226-60-5
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 213.23 Da
- Molecular formula
- C10H15NO4
- PubChem identifier
- 9794358
- Nature
- Synthetic
Recommended products
MW 213.23 Da, Purity >95%. Potent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro.
Key facts
- CAS number
- 154226-60-5
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 213.23 Da
- Molecular formula
- C10H15NO4
- PubChem identifier
- 9794358
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 75 mM.
Soluble in water to 10 mM.
- Biochemical name
- Clasto-lactacystin beta-lactone
- Biological description
Potent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro.
- Canonical SMILES
- CC1C2C(C(=O)O2)(NC1=O)C(C(C)C)O
- Isomeric SMILES
- C[C@@H]1[C@H]2[C@](C(=O)O2)(NC1=O)[C@H](C(C)C)O
- InChI
- InChI=1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
- InChIKey
- FWPWHHUJACGNMZ-NBBQQVJHSA-N
- IUPAC name
- (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1710 Clasto-Lactacystin ß-lactone. 1710-100 is the same size as the 100 μg size of ab141412.
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1 product image
Chemical Structure - clasto-Lactacystin beta-lactone, 20S proteasome inhibitor (ab141412)
2D chemical structure image of ab141412, clasto-Lactacystin beta-lactone, 20S proteasome inhibitor
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