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AB213715

CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative

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(5 Publications)

MW 262.65 Da. Thymidine analogue, readily incorporated following phosphorylation, into newly synthesized DNA in place of thymidine. Used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors.
1 Images
Chemical Structure - CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative (AB213715)
  • Chemical Structure

Lab

Chemical Structure - CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative (AB213715)

2D chemical structure image of ab213715, CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative

Key facts

CAS number

50-90-8

Form

Solid

form

Molecular weight

262.65 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>1</sub>ClN<sub>2</sub>O<sub>5</sub>

PubChem

65510

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

5-Chloro-2'-deoxyuridine

Biological description

Thymidine analogue, readily incorporated following phosphorylation, into newly synthesized DNA in place of thymidine. Used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors.

Canonical smiles

C1C(C(OC1N2C=C(C(=O)NC2=O)Cl)CO)O

Isomeric smiles

C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)O

InChi

InChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChiKey

NJCXGFKPQSFZIB-RRKCRQDMSA-N

IUPAC Name

5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

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Complementary Products

Biochemicals

AB142581

Idoxuridine, Antiviral thymidine analog

Chemical Structure - Idoxuridine, Antiviral thymidine analog (AB142581)

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  • 0
Primary Antibodies

AB6326

Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker

Flow Cytometry (Intracellular) - Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker (AB6326)

  • 5
  • 104
Primary Antibodies

AB8152

Anti-BrdU antibody [IIB5]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BrdU antibody [IIB5] (AB8152)

  • 5
  • 7
Primary Antibodies

AB152095

Anti-BrdU antibody

Immunocytochemistry/ Immunofluorescence - Anti-BrdU antibody (AB152095)

  • 4
  • 4
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed35416772

2022

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.

Applications

Unspecified application

Species

Unspecified reactive species

Sandhya Balasubramanian,Matteo Andreani,Júlia Goncalves Andrade,Tannishtha Saha,Devakumar Sundaravinayagam,Javier Garzón,Wenzhu Zhang,Oliver Popp,Shin-Ichiro Hiraga,Ali Rahjouei,Daniel B Rosen,Philipp Mertins,Brian T Chait,Anne D Donaldson,Michela Di Virgilio

Cancer research 82:998-1012 PubMed35078814

2022

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Julie Devin,Tatiana Cañeque,Yea-Lih Lin,Lucie Mondoulet,Jean-Luc Veyrune,Matthieu Abouladze,Elvira Garcia De Paco,Ouissem Karmous Gadacha,Guillaume Cartron,Philippe Pasero,Caroline Bret,Raphaël Rodriguez,Jerome Moreaux

Bio-protocol 10:e3798 PubMed33659452

2020

Estimation of the Minimum Number of Replication Origins Per Chromosome in any Organism.

Applications

Unspecified application

Species

Unspecified reactive species

Marcelo S Da Silva

Bio-protocol 8:e3125 PubMed34532563

2018

Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in .

Applications

Unspecified application

Species

Unspecified reactive species

Marcelo S da Silva,Paula A Marin,Bruno M Repolês,Maria C Elias,Carlos R Machado

Cell 172:1063-1078.e19 PubMed29474907

2018

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

Applications

Unspecified application

Species

Mouse

Carla G Silva,Elise Peyre,Mohit H Adhikari,Sylvia Tielens,Sebastian Tanco,Petra Van Damme,Lorenza Magno,Nathalie Krusy,Gulistan Agirman,Maria M Magiera,Nicoletta Kessaris,Brigitte Malgrange,Annie Andrieux,Carsten Janke,Laurent Nguyen
View all publications
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Product promise

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