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MW 305.5 Da, Purity >97%. Metal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease). Effects on Alzheimer's disease attributed to copper and zinc chelation or increased level of a metalloprotease. Other actions reported including iron chelation, inhibition of Huntington expression from its mRNA, proteasome inhibition when complexed with copper, and stimulation of tumor necrosis factor-α secretion. Also inhibitor of CLK-1/MCLK1 (an aging-associated protein).

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Images

Chemical Structure - Clioquinol, Metal chelator and ionophore (AB120355), expandable thumbnail

Key facts

CAS number
130-26-7
Purity
> 97%
Form
Solid
Molecular weight
305.5 Da
Molecular formula
C9H5ClINO
PubChem identifier
2788
Nature
Synthetic

Alternative names

Recommended products

MW 305.5 Da, Purity >97%. Metal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease). Effects on Alzheimer's disease attributed to copper and zinc chelation or increased level of a metalloprotease. Other actions reported including iron chelation, inhibition of Huntington expression from its mRNA, proteasome inhibition when complexed with copper, and stimulation of tumor necrosis factor-α secretion. Also inhibitor of CLK-1/MCLK1 (an aging-associated protein).

Key facts

Purity
> 97%
PubChem identifier
2788
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Clioquinol
Biological description

Metal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease). Effects on Alzheimer's disease attributed to copper and zinc chelation or increased level of a metalloprotease. Other actions reported including iron chelation, inhibition of Huntington expression from its mRNA, proteasome inhibition when complexed with copper, and stimulation of tumor necrosis factor-α secretion. Also inhibitor of CLK-1/MCLK1 (an aging-associated protein).

Canonical SMILES
C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
InChI
InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKey
QCDFBFJGMNKBDO-UHFFFAOYSA-N
IUPAC name
5-chloro-7-iodoquinolin-8-ol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - Clioquinol, Metal chelator and ionophore (ab120355), expandable thumbnail

    Chemical Structure - Clioquinol, Metal chelator and ionophore (ab120355)

    2D chemical structure image of ab120355, Clioquinol, Metal chelator and ionophore

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Product protocols

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