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AB142856

Clobetasol propionate, Glucocorticoid

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MW 467 Da, Purity >98%. Glucocorticoid, induces monooxygenase activity in vivo. Alters the structure of tight junctions in epidermis. Smoothened hedgehog pathway receptor agonist. Anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo.

View Alternative Names

2700049B16Rik, 3110031N04Rik, AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Drosophila slowpoke like, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, HUMARA, HYSP1, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, KD, Kennedy disease (KD), LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, NR3C3, NR3C4, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), PGR, PR, PRA, PRB, PRGR_HUMAN, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, SAKCA, SBMA, SLO, SMAX1, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, Testicular Feminization (TFM), androgen receptor splice variant 4b, bA350O14.10, cytokeratin-associated protein, glucocorticoid nuclear receptor variant 1, hSlo, hslo beta, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4

1 Images
Chemical Structure - Clobetasol propionate, Glucocorticoid (AB142856)
  • Chemical Structure

Lab

Chemical Structure - Clobetasol propionate, Glucocorticoid (AB142856)

2D chemical structure image of ab142856, Clobetasol propionate, Glucocorticoid

Key facts

CAS number

25122-46-7

Purity

>98%

Form

Solid

form

Molecular weight

467 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>2</sub>ClFO<sub>5</sub>

PubChem

32798

Nature

Synthetic

Biochemical name

Clobetasol propionate

Biological description

Glucocorticoid, induces monooxygenase activity in vivo. Alters the structure of tight junctions in epidermis. Smoothened hedgehog pathway receptor agonist. Anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo.

Canonical smiles

CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl

Isomeric smiles

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl

InChi

InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

InChiKey

CBGUOGMQLZIXBE-XGQKBEPLSA-N

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The targets Glucocorticoid Receptor Progesterone Receptor Maxi Potassium channel alpha (SLO) Maxi Potassium channel beta (KCNMB1) Androgen Receptor KCNMB4 KCNMB2 and LRRC26 perform distinct mechanical functions in cells. The Glucocorticoid Receptor also known as NR3C1 acts as a transcription factor and is found in cytoplasm. It is about 97 kDa in weight and expressed in many tissues including kidney brain and liver. The Progesterone Receptor or PGR modulates gene expression and is widely expressed in reproductive tissues. The Maxi Potassium channels also known as BK channels consist of alpha and beta subunits like SLO and KCNMB1 KCNMB2 KCNMB4 which contribute to membrane potential regulation and are primarily located in the nervous system and muscles. LRRC26 associated with BK channels acts as an auxiliary subunit to modulate channel activity.
Biological function summary

These targets play integral roles in various physiological processes. The Glucocorticoid Receptor mediates the effects of stress by regulating genes that control metabolism and immune responses. Maxi Potassium channels formed by combinations of SLO and KCNMB proteins regulate potassium ion flow to maintain cellular excitability and vascular tone. The Androgen Receptor influences male sexual development and bone density by controlling the expression of androgen-responsive genes. Together these targets often participate in complexes that integrate signals across cells modulating tissue-specific responses to hormones and external stimuli.

Pathways

Each target protein fits into key biological signaling cascades that maintain homeostasis. The Glucocorticoid Receptor and Androgen Receptor are parts of the steroid hormone signaling pathways influencing genes involved in metabolism inflammation and cell growth. Maxi Potassium channels including their alpha and beta subunits are involved in the calcium signaling pathway affecting neurotransmission and muscle contraction. These pathways involve multiple proteins and cross-talk with other pathways interacting with proteins like estrogen receptors and kinase enzymes.

These targets have significant implications in human health. The Glucocorticoid Receptor is linked to Cushing's syndrome and chronic stress disorders where dysregulation leads to disturbed cortisol production. Androgen Receptor abnormalities are associated with prostate cancer and androgen insensitivity syndrome reflecting disrupted androgen signaling. Maxi Potassium channels interact with proteins like calcium-activated potassium channel blockers and are implicated in hypertension and epilepsy where ion channel dysfunction alters neuronal excitability and blood pressure regulation.
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Product protocols

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