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AB120019

Clozapine, Atypical antipsychotic

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(3 Publications)

MW 326.8 Da, Purity >98%. Atypical antipsychotic compound. Broad range of actions including antagonism at D4, D2, 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors. Also agonist at muscarinic receptors.
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Chemical Structure - Clozapine, Atypical antipsychotic (AB120019)
  • Chemical Structure

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Chemical Structure - Clozapine, Atypical antipsychotic (AB120019)

2D chemical structure image of ab120019, Clozapine, Atypical antipsychotic

Key facts

CAS number

5786-21-0

Purity

>98%

Form

Solid

form

Molecular weight

326.8 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>9</sub>ClN<sub>4</sub>

PubChem

2818

Nature

Synthetic

Solubility

Soluble in 2 eq. HCl to 50 mM

Biochemical name

CID 2818

Biological description

Atypical antipsychotic compound. Broad range of actions including antagonism at D4, D2, 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors. Also agonist at muscarinic receptors.

Canonical smiles

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Isomeric smiles

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

InChi

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

InChiKey

ZUXABONWMNSFBN-UHFFFAOYSA-N

IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Psychopharmacology 231:269-81 PubMed23954911

2013

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.

Applications

Unspecified application

Species

Rat

Katarzyna Fijał,Piotr Popik,Agnieszka Nikiforuk

Journal of psychopharmacology (Oxford, England) 27:469-76 PubMed23479455

2013

The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Nikiforuk,Katarzyna Fijał,Agnieszka Potasiewicz,Piotr Popik,Tomasz Kos

Neuroscience 167:456-74 PubMed20167261

2010

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

S D Greenhill,R S G Jones
View all publications
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