AB141704

Clozapine N-oxide, Metabolite of Clozapine

Name: Clozapine N-oxide, Metabolite of Clozapine (ab141704) | Abcam
Brand: Abcam Limited
SKU: AB141704
Price: 165 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(37 Publications)

Clozapine N-oxide (CNO) (ab141704) is a metabolite of atypical antipsychotic Clozapine (ab120019). Ligand for human muscarinic acetylcholine receptors, designer receptors activated by designer drugs (DREADD). MW 342.8,

- Active in vitro and in vivo.

1 Images

Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (AB141704)

Chemical Structure

Lab

Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (AB141704)

2D chemical structure image of ab141704, Clozapine N-oxide, Metabolite of Clozapine

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

342.8 Da

Molecular formula

C18H19ClN4O

PubChem

36727

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Dtxsid50955778

Biological description

Metabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.

Canonical smiles

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl

InChi

InChI=1S/C18H19ClN4O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)23(18)24/h2-7,12,24H,8-11H2,1H3

InChiKey

YWSTWDVPYHSYLN-UHFFFAOYSA-N

IUPAC Name

3-chloro-5-hydroxy-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepine

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Product details

Check out our range of Clozapine biochemicals here

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (37)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:5215 PubMed40473608

2025

A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mingli Qu,Qun Wang,Xiaofei Bai,Jing Feng,Sai Zhang,Yangyang Zhang,Qing Chen,Hai Zhu,Hengrui Zhang,Qunqin Guo,Bin Zhang,Shengqian Dou,Yujie Qiao,Hongwei Wang,Yihai Cao,Lixin Xie,Qingjun Zhou

The Journal of neuroscience : the official journal of the Society for Neuroscience 45: PubMed40404352

2025

Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Ruoshi Li,Ran Inoue,Hisashi Mori,Arisa Hirano,Takeshi Sakurai

Journal of cachexia, sarcopenia and muscle 16:e13782 PubMed40196908

2025

Activating Striatal Parvalbumin Interneurons to Alleviate Chemotherapy-Induced Muscle Atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Hu,Jingyuan Liu,Yuqing Yan,Ziyu Shen,Junlong Sun,Yongjun Zheng

Science advances 11:eadn1335 PubMed39813346

2025

Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Soya,Koji Toda,Katsuyasu Sakurai,Yoan Cherasse,Yuki C Saito,Manabu Abe,Kenji Sakimura,Takeshi Sakurai

Sleep advances : a journal of the Sleep Research Society 5:zpae091 PubMed39717113

2024

Chemogenetic activation of astrocytes modulates sleep-wakefulness states in a brain region-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Yuta Kurogi,Tomomi Sanagi,Daisuke Ono,Tomomi Tsunematsu

Nature communications 15:9887 PubMed39543166

2024

Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yang,Mengdi Zhang,Yuan Zhou,Dongxiao Jiang,Lilong Yu,Lingyu Xu,Fan Fei,Wenkai Lin,Yanrong Zheng,Jiannong Wu,Yi Wang,Zhong Chen

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2410927 PubMed39435757

2024

Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongxia Li,Liying Chen,Fan Fei,Wenqi Wang,Lin Yang,Yu Wang,Heming Cheng,Yingwei Xu,Cenglin Xu,Shuang Wang,Yan Gu,Feng Han,Zhong Chen,Yi Wang

The journal of headache and pain 25:140 PubMed39192198

2024

Ventral posteromedial nucleus of the thalamus gates the spread of trigeminal neuropathic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Du,Shi-Da Lin,Xue-Qing Wu,Bao-Yu Xue,Yi-La Ding,Jia-Hang Zhang,Bei Tan,Guo-Dong Lou,Wei-Wei Hu,Zhong Chen,Shi-Hong Zhang

Nature communications 15:5353 PubMed38918403

2024

Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release.

Applications

Unspecified application

Species

Unspecified reactive species

Xuehan Zhou,Carrie Stine,Patricia Oliveira Prada,Debora Fusca,Kevin Assoumou,Jan Dernic,Musadiq A Bhat,Ananya S Achanta,Joseph C Johnson,Amanda Loren Pasqualini,Sanjana Jadhav,Corinna A Bauder,Lukas Steuernagel,Luca Ravotto,Dietmar Benke,Bruno Weber,Azra Suko,Richard D Palmiter,Miriam Stoeber,Peter Kloppenburg,Jens C Brüning,Michael R Bruchas,Tommaso Patriarchi

Nature metabolism 6:473-493 PubMed38378998

2024

Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Alain J De Solis,Almudena Del Río-Martín,Jan Radermacher,Weiyi Chen,Lukas Steuernagel,Corinna A Bauder,Fynn R Eggersmann,Donald A Morgan,Anna-Lena Cremer,Michael Sué,Maximilian Germer,Christian Kukat,Stefan Vollmar,Heiko Backes,Kamal Rahmouni,Peter Kloppenburg,Jens C Brüning

View all publications

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Clozapine N-oxide, Metabolite of Clozapine

Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (AB141704)

Key facts

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Product details

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (37)

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