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AB120017

CNQX, AMPA / kainate antagonist

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(74 Publications)

MW 232.15 Da, Purity >99%. Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
3 Images
Immunocytochemistry/ Immunofluorescence - CNQX, AMPA / kainate antagonist (AB120017)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - CNQX, AMPA / kainate antagonist (AB120017)

ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with CNQX (ab120017), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of CNQX, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120017 (CNQX) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Cellular Activation - CNQX, AMPA / kainate antagonist (AB120017)
  • CellAct

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Cellular Activation - CNQX, AMPA / kainate antagonist (AB120017)

Left and Middle : Representative IOS amplitude map and field response curve under control condition and under application of 20 µM CNQX, respectively. The colorbar indicates the maximum change of the transmittance compared to the resting light intensity. A Right : Spatial visualization of the percentage of control changes of IOS signal caused by CNQX application.

Image from Ildiko P, et al. Plos One, 8(3), e57694. Fig 4a,; doi: 110.1371/journal.pone.0057694

Chemical Structure - CNQX, AMPA / kainate antagonist (AB120017)
  • Chemical Structure

Lab

Chemical Structure - CNQX, AMPA / kainate antagonist (AB120017)

2D chemical structure image of ab120017, CNQX, AMPA / kainate antagonist

Key facts

CAS number

115066-14-3

Purity

>99%

Form

Solid

form

Molecular weight

232.15 Da

Molecular formula

C<sub>9</sub>H<sub>4</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

3721046

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

6-Cyano-7-nitroquinoxaline-2,3-dione

Biological description

Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

Canonical smiles

C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N

InChi

InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChiKey

RPXVIAFEQBNEAX-UHFFFAOYSA-N

IUPAC Name

7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile

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Secondary Antibodies

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate Receptor 1 (AMPA subtype) also known as GluA1 or GRIA1 is an ionotropic glutamate receptor that functions as a ligand-gated ion channel. It is part of the AMPA receptor complex. The AMPA receptor modulates synaptic transmission and plasticity by allowing the flow of Na+ and K+ ions upon binding of the neurotransmitter glutamate. These receptors are widely expressed throughout the central nervous system with significant expression in the hippocampus and cerebral cortex regions important for memory and learning. The approximate molecular weight of GluA1 is 99.3 kDa.
Biological function summary

Glutamate Receptor 1 plays a pivotal role in excitatory synaptic transmission. It forms tetrameric complexes often including other AMPA receptor subunits like GluA2 GluA3 and GluA4. The assembly of these subunits influences the ion permeability and kinetic properties of the receptor further impacting synaptic strength and plasticity. The receptor's function is important for long-term potentiation (LTP) a cellular mechanism for learning and memory in the brain.

Pathways

The function of Glutamate Receptor 1 is integral to the glutamatergic signaling pathway an essential pathway for excitatory neurotransmission. It interacts with few other proteins like NMDA receptors which also play an important role in synaptic plasticity and are involved in several synaptic signaling cascades. This receptor is also part of the MAPK signaling pathway which is important in synaptic development and neuronal survival. The crosstalk between AMPA receptors and NMDA receptors allows fine-tuning of synaptic responses and plasticity.

Glutamate Receptor 1 is implicated in neurological conditions such as Alzheimer's disease and epilepsy. Altered expression or dysfunction of this receptor can lead to synaptic failure and neurodegeneration commonly observed in Alzheimer's disease. In epilepsy aberrant regulation of AMPA receptor-mediated signaling contributes to excessive excitatory neurotransmission and seizures. The receptor's interaction with NMDA receptors is a focus for therapeutic interventions aiming to regulate excessive activity in these disorders.
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Product protocols

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Publications (74)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 7:1707 PubMed39730868

2024

Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCN neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhang,Wei Wang,Jiaxin Li,Dongmei Zhao,Yue Shu,Xinlu Jia,Yibo Wang,Xinqi Cheng,Liecheng Wang,Juan Cheng

Neurochemical research 49:2926-2939 PubMed39078522

2024

Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhang,Jiaxin Li,Yan Li,Wei Wang,Daming Wang,Junli Ding,Licheng Wang,Juan Cheng

Heliyon 9:e20620 PubMed37876454

2023

Isoliquiritigenin modulates the activity of LTS and non-LTS cells in the ventrolateral preoptic area via GABA receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Sumei Fan,Qiaoling Jin,Pingping Zhang,Dejiao Xu,Juan Cheng,Liecheng Wang

Frontiers in synaptic neuroscience 14:910820 PubMed35844900

2022

Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Gary C Mouradian,Pengyuan Liu,Pablo Nakagawa,Erin Duffy,Javier Gomez Vargas,Kirthikaa Balapattabi,Justin L Grobe,Curt D Sigmund,Matthew R Hodges

Cells 10: PubMed34831454

2021

Scavenging Tumor Necrosis Factor α Does Not Affect Inhibition of Dentate Granule Cells Following In Vitro Entorhinal Cortex Lesion.

Applications

Unspecified application

Species

Unspecified reactive species

Dimitrios Kleidonas,Andreas Vlachos

eLife 9: PubMed33185190

2020

The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.

Applications

Unspecified application

Species

Unspecified reactive species

Shaun S Sanders,Luiselys M Hernandez,Heun Soh,Santi Karnam,Randall S Walikonis,Anastasios V Tzingounis,Gareth M Thomas

eLife 7: PubMed30382937

2018

Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission.

Applications

Unspecified application

Species

Unspecified reactive species

Heun Soh,Suhyeorn Park,Kali Ryan,Kristen Springer,Atul Maheshwari,Anastasios V Tzingounis

Nature communications 9:52 PubMed29302029

2018

A neural basis for antagonistic control of feeding and compulsive behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Leandra R Mangieri,Yungang Lu,Yuanzhong Xu,Ryan M Cassidy,Yong Xu,Benjamin R Arenkiel,Qingchun Tong

Experimental neurology 283:16-28 PubMed27246999

2016

Primary blast injury causes cognitive impairments and hippocampal circuit alterations.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew Beamer,Shanti R Tummala,David Gullotti,Catherine Kopil,Samuel Gorka, Ted Abel,Cameron R Dale Bass,Barclay Morrison,Akiva S Cohen,David F Meaney

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:14957-65 PubMed26558769

2015

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren M Hablitz,Hylton E Molzof,Kathryn E Abrahamsson,Joanna M Cooper,Rebecca A Prosser,Karen L Gamble
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