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AB120044

CNQX disodium salt, AMPA / kainate antagonist

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(44 Publications)

CNQX disodium salt (ab120044) is a competitive and potent AMPA / kainate receptor antagonist with IC50s of 0.3 µM and 1.5 µM, respectively. MW 276.12.

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Chemical Structure - CNQX disodium salt, AMPA / kainate antagonist (AB120044)
  • Chemical Structure

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Chemical Structure - CNQX disodium salt, AMPA / kainate antagonist (AB120044)

2D chemical structure image of ab120044, CNQX disodium salt, AMPA / kainate antagonist

Functional Studies - CNQX disodium salt, AMPA / kainate antagonist (AB120044)
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Functional Studies - CNQX disodium salt, AMPA / kainate antagonist (AB120044)

ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with CNQX disodium salt (ab120044), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of CNQX disodium salt, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120044 (CNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Key facts

CAS number

479347-85-8

Purity

>99%

Form

Solid

form

Molecular weight

276.12 Da

Molecular formula

C<sub>9</sub>H<sub>2</sub>N<sub>4</sub>Na<sub>2</sub>O<sub>4</sub>

PubChem

6093155

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biochemical name

CNQX disodium salt

Canonical smiles

C1=C(C(=CC2=C1N=C(C(=N2)[O-])[O-])[N+](=O)[O-])C#N.[Na+].[Na+]

InChi

InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2

IUPAC Name

disodium;6-cyano-7-nitroquinoxaline-2,3-diolate

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Picrotoxin, GABAA antagonist

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Biochemicals

AB120045

NBQX, AMPA / kainate antagonist

Chemical Structure - NBQX, AMPA / kainate antagonist (AB120045)

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Product details

Check out our range of AMPA / kainate antagonist here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dysfunction in GluR1 and associated AMPA receptors has been implicated in conditions like Alzheimer's disease and epilepsy. Alzheimer's disease exhibits decreased synaptic transmission and plasticity linked to impaired GluR1 function and its interactions with NMDA receptors. In epilepsy abnormal GluR1 activity may contribute to heightened neuronal excitability and seizure propagation. Targeting GluR1 or associated pathways offers potential for therapeutic interventions in these disorders possibly through drugs such as memantine and NBQX which modulate receptor activity.
Pathways

The GluR1-containing AMPA receptors participate significantly in the glutamatergic signaling pathway which is vital for fast excitatory synaptic transmission in the brain. This pathway also involves the NMDA receptors which work together with AMPA receptors to regulate synaptic plasticity and neuronal communication. Additionally the GluR1 interacts within the long-term potentiation (LTP) pathway contributing to the strengthening of synapses an essential mechanism underlying learning and memory.

Biological function summary

The GluR1 subunit is an essential component of the AMPA receptor complex which typically forms as a tetramer. This complex modulates synaptic strength and plasticity processes critical for learning and memory. The activity of AMPA receptors including those containing GluR1 is regulated by several auxiliary proteins and is essential for post-synaptic responses. The GluR1 subunit also interacts with other proteins such as TARPs which modulate its trafficking and channel properties.

Glutamate Receptor 1 (AMPA subtype) also known as GluR1 is a subunit of the AMPA receptor complex which mediates fast synaptic transmission in the central nervous system. It is an ionotropic receptor for glutamate functioning by opening ion channels to allow the flow of Na+ and Ca2+ ions across the cell membrane contributing to excitatory neurotransmission. The GluR1 subunit has a molecular mass of approximately 100 kDa. This receptor is commonly expressed in the brain regions such as the hippocampus and the cerebral cortex playing an important role in synaptic plasticity and memory formation.
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Product protocols

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Publications (44)

Recent publications for all applications. Explore the full list and refine your search

Molecular autism 16:26 PubMed40241211

2025

Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Bonnycastle,Mohammed Sarfaraz Nawaz,Peter C Kind,Michael A Cousin

EMBO reports 25:351-377 PubMed38177913

2024

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Km Jörgensen,Alena Karnošová,Simone Mazzaferro,Oliver Rowley,Hsiao-Jou Cortina Chen,Sarah J Robbins,Sarah Christofides,Florian T Merkle,Lenka Maletínská,David Petrik

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:7149-7157 PubMed37775302

2023

Evidence That Ultrafast Nonquantal Transmission Underlies Synchronized Vestibular Action Potential Generation.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J Pastras,Ian S Curthoys,Mohsen Asadnia,David McAlpine,Richard D Rabbitt,Daniel J Brown

Nature communications 14:5285 PubMed37648685

2023

Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Bonnycastle,Katharine L Dobson,Eva-Maria Blumrich,Akshada Gajbhiye,Elizabeth C Davenport,Marie Pronot,Moritz Steinruecke,Matthias Trost,Alfredo Gonzalez-Sulser,Michael A Cousin

Cell reports 42:112699 PubMed37368752

2023

T-type Ca and persistent Na currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Topczewska,Elisabetta Giacalone,Wendy S Pratt,Michele Migliore,Annette C Dolphin,Mala M Shah

Current protocols 3:e786 PubMed37272700

2023

Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Hsiao-Jou Cortina Chen,Simone Mazzaferro,Tian Tian,Iman Mali,Florian T Merkle

Journal of neurochemistry 166:248-264 PubMed37243578

2023

The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Christiana Kontaxi,Nawon Kim,Michael A Cousin

Molecular therapy. Methods & clinical development 30:1-13 PubMed37324975

2023

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.

Applications

Unspecified application

Species

Unspecified reactive species

Yusaku Katada,Hiromitsu Kunimi,Naho Serizawa,Deokho Lee,Kenta Kobayashi,Kazuno Negishi,Hideyuki Okano,Kenji F Tanaka,Kazuo Tsubota,Toshihide Kurihara

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:3421-3438 PubMed36997314

2023

Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons.

Applications

Unspecified application

Species

Unspecified reactive species

Jason D Vevea,Edwin R Chapman

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:2002-2020 PubMed36759195

2023

Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Christiana Kontaxi,Daniela Ivanova,Elizabeth C Davenport,Peter C Kind,Michael A Cousin
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