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AB144488

CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble)

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(7 Publications)

MW 276.12 Da, Purity >99%. Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

View Alternative Names

AMPA 1, AMPA-selective glutamate receptor 1, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243

2 Images
Flow Cytometry - CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble) (AB144488)
  • Flow Cyt

PubMed

Flow Cytometry - CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble) (AB144488)

Effects of cortical and nuclear CNQX on performance of established CRs.

Mean (±1 SEM) effects of CNQX (6 nmol) on CR performance when infused into cortical (2 μl; top panels) or nuclear cannulae (1 μl; bottom panels).

(From Figure 4 of Kellett et al).

Kellett et al PLoS One. 2010; 5(7): e11737. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble) (AB144488)
  • Chemical Structure

Lab

Chemical Structure - CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble) (AB144488)

2D chemical structure image of ab144488, CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble)

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

276.12 Da

Molecular formula

C<sub>9</sub>H<sub>2</sub>N<sub>4</sub>Na<sub>2</sub>O<sub>4</sub>

PubChem

2821

Nature

Synthetic

Solubility

Soluble in 1 ml of water to give specified mM/ml concentration

Biochemical name

CNQX disodium

Biological description

Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

Canonical smiles

C1=C(C(=CC2=C1N=C(C(=N2)[O-])[O-])[N+](=O)[O-])C#N.[Na+].[Na+]

InChi

InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2

InChiKey

YCXDDPGRZKUGDG-UHFFFAOYSA-L

IUPAC Name

disodium;6-cyano-7-nitroquinoxaline-2,3-diolate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 286:19993-20004 PubMed21482824

2011

Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Young-Hwan Jo,Emmanuelle Donier,Audrey Martinez,Maurice Garret,Estelle Toulmé,Eric Boué-Grabot

Hippocampus 22:516-33 PubMed21254303

2011

Adrenergic modulation of sharp wave-ripple activity in rat hippocampal slices.

Applications

Unspecified application

Species

Unspecified reactive species

R Ul Haq,A Liotta,R Kovacs,A Rösler,M J Jarosch,U Heinemann,C J Behrens

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25:1002-13 PubMed21148112

2010

Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning.

Applications

Unspecified application

Species

Unspecified reactive species

Stefanie Tinnes,Michael K E Schäfer,Armin Flubacher,Gert Münzner,Michael Frotscher,Carola A Haas

The Journal of physiology 589:283-95 PubMed21078589

2010

The dynamics of single spike-evoked adenosine release in the cerebellum.

Applications

Unspecified application

Species

Unspecified reactive species

Boris P Klyuch,Magnus J E Richardson,Nicholas Dale,Mark J Wall

Journal of neurophysiology 105:172-87 PubMed20881199

2010

Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices.

Applications

Unspecified application

Species

Unspecified reactive species

Agustin Liotta,Gürsel Caliskan,Rizwan ul Haq,Jan O Hollnagel,Anton Rösler,Uwe Heinemann,Christoph J Behrens

PloS one 5:e11737 PubMed20686596

2010

Memory consolidation in the cerebellar cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel O Kellett,Izumi Fukunaga,Eva Chen-Kubota,Paul Dean,Christopher H Yeo

The Journal of physiology 588:2047-63 PubMed20351046

2010

Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

William M Connelly,George Lees
View all publications
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