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AB120663

Colchicine from Colchicum autumnale, microtubule formation inhibitor

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(3 Publications)

MW 399.44 g/mol, Purity >99%. Inhibitor of microtubule formation (Ki = 2.1 μM). Antimitotic, anti-inflammatory and antifibrotic activity. Unable to cross the blood-brain barrier.
1 Images
Chemical Structure - Colchicine from Colchicum autumnale, microtubule formation inhibitor (AB120663)
  • Chemical Structure

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Chemical Structure - Colchicine from Colchicum autumnale, microtubule formation inhibitor (AB120663)

2D chemical structure image of ab120663, Colchicine from Colchicum autumnale, microtubule formation inhibitor

Key facts

CAS number

64-86-8

Purity

>99%

Form

Solid

form

Source

Colchicum autumnale

Molecular weight

399.44 g/mol

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>5</sub>NO<sub>6</sub>

Nature

Native

Solubility

Soluble in water to 10 mM

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biological description

Inhibitor of microtubule formation (Ki = 2.1 μM). Antimitotic, anti-inflammatory and antifibrotic activity. Unable to cross the blood-brain barrier.

IUPAC Name

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

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Product details

Light sensitive
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:953272 PubMed36311768

2022

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Ana P Pinto,Vitor R Muñoz,Alisson L da Rocha,Rafael L Rovina,Gustavo D Ferrari,Luciane C Alberici,Fernando M Simabuco,Giovana R Teixeira,José R Pauli,Leandro P de Moura,Dennys E Cintra,Eduardo R Ropelle,Ellen C Freitas,Donato A Rivas,Adelino S R da Silva

International journal of molecular sciences 22: PubMed33807902

2021

Impact of Different Physical Exercises on the Expression of Autophagy Markers in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ana P Pinto,Alisson L da Rocha,Bruno B Marafon,Rafael L Rovina,Vitor R Muñoz,Lilian E C M da Silva,José R Pauli,Leandro P de Moura,Dennys E Cintra,Eduardo R Ropelle,Adelino S R da Silva

International journal of molecular sciences 21: PubMed33182536

2020

Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Alisson L da Rocha,Ana P Pinto,Gustavo P Morais,Bruno B Marafon,Rafael L Rovina,Allice S C Veras,Giovana R Teixeira,José R Pauli,Leandro P de Moura,Dennys E Cintra,Eduardo R Ropelle,Donato A Rivas,Adelino S R da Silva
View all publications
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