Compound 401, DNA-dependent protein kinase and mTOR inhibitor

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MW 281.31 Da, Purity >99%. Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC₅₀ values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC₅₀ values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.

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DNA PK, DNA-PK catalytic subunit, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNPK 1, FK506 binding protein 12 rapamycin associated protein 1, FK506 binding protein 12 rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, FLJ44809, FRAP, FRAP1, FRAP2, HYRC, HYRC 1, Hyper radiosensitivity of murine scid mutation, complementing 1, Hyperradiosensitivity complementing 1, mouse, homolog of 1, IMD26, MTOR_HUMAN, Mammalian target of rapamycin, Mechanistic target of rapamycin, OTTHUMP00000001983, PKRDC, PRKDC_HUMAN, Protein Kinase DNA Activated Catalytic Polypeptide, RAFT1, RAPT1, Rapamycin and FKBP12 target 1, Rapamycin associated protein FRAP2, Rapamycin target protein, Rapamycin target protein 1, Serine/threonine-protein kinase mTOR, XRCC 7, dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1), p350, p460