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AB144525

Compound A, glucocorticoid receptor (GR) modulator

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(1 Publication)

MW 264.14 Da, Purity >98%. Cell-permeable, nonsteroidal glucocorticoid receptor (GR) modulator. Exhibits 4-fold higher binding affinity to GR than dexamethasone (ab120743). Down modulates TNF-induced gene expression and shows immunosuppressant activity. Active in vitro.

Key facts

CAS number

14593-25-0

Purity

>98%

Molecular weight

264.14 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>5</sub>Cl<sub>2</sub>NO<sub>2</sub>

PubChem

9838147

Nature

Synthetic

Solubility

Soluble in water

Soluble in ethanol to 10 mM

Soluble in DMSO to 25 mM

Biochemical name

4-[1-Chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride

Biological description

Cell-permeable, nonsteroidal glucocorticoid receptor (GR) modulator. Exhibits 4-fold higher binding affinity to GR than dexamethasone (ab120743). Down modulates TNF-induced gene expression and shows immunosuppressant activity. Active in vitro.

Canonical smiles

CC(=O)OC1=CC=C(C=C1)C(CNC)Cl.Cl

InChi

InChI=1S/C11H14ClNO2.ClH/c1-8(14)15-10-5-3-9(4-6-10)11(12)7-13-2;/h3-6,11,13H,7H2,1-2H3;1H

InChiKey

WKMYTPCPAWZWII-UHFFFAOYSA-N

IUPAC Name

[4-[1-chloro-2-(methylamino)ethyl]phenyl] acetate;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular carcinogenesis 60:644-657 PubMed34169564

2021

ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B.

Applications

Unspecified application

Species

Unspecified reactive species

Hongtao Gong,Liu Liu,Lina Cui,Hongyan Ma,Liyun Shen
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Complementary Products

Primary Antibodies

AB183127

Anti-Glucocorticoid Receptor antibody [EPR19621]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Glucocorticoid Receptor antibody [EPR19621] (AB183127)

  • 5
  • 2
Proteins & Peptides

AB235857

Recombinant Human Androgen Receptor protein (Tagged)

SDS-PAGE - Recombinant Human Androgen Receptor protein (Tagged) (AB235857)

  • 0
  • 0
Biochemicals

AB120743

Dexamethasone, anti-inflammatory glucocorticoid

Chemical Structure - Dexamethasone, anti-inflammatory glucocorticoid (AB120743)

  • 0
  • 0
Biochemicals

AB145206

(±)-1,2-Didecanoylglycerol (10:0), Protein kinase C activator

  • 0
  • 0

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