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AB143597

Corticosterone, endogenous steroid hormone

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(7 Publications)

MW 346.5 Da, Purity >98%. Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable.

View Alternative Names

ABP, ACLS, AIS, ANDR_HUMAN, AR, AR8, Aldosterone receptor, Androgen binding protein, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), CBG_HUMAN, Corticosteroid-binding globulin, DHTR, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), EMT, EMT organic cation transporter 3, EMTH, Extraneuronal monoamine transporter, GCCR, GCPS, GCRST, GCR_HUMAN, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GR, Glioma associated oncogene family zinc finger 3, Glucocorticoid receptor, Grl1, HUMARA, HYSP1, KD, Kennedy disease (KD), MCR_HUMAN, MGC133092, MLR, MR, Mineralocorticoid receptor, NF-E2-related factor 2, NF2L2_HUMAN, NR3 C2, NR3C2 protein, NR3C3, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 2, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Oct-03, Oncogene GLI3, Orct 3, Organic cation transporter 3, PAP A, PAPB, PGR, PPD IV, PR, PRA, PRB, PRGR_HUMAN, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, S22A3_HUMAN, SBMA, SBP, SHBG_HUMAN, SLC22 A3, SLC22A 3, SMAX1, Serpin A6, Sex hormone-binding globulin, Sex steroid-binding protein, Slc22a3, Solute carrier family 22 (extraneuronal monoamine transporter) member 3, Solute carrier family 22 (organic cation transporter) member 3, Solute carrier family 22 member 3, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TeBG, Testicular Feminization (TFM), Testis-specific androgen-binding protein, Testosterone binding beta globulin, Testosterone-estradiol-binding globulin, Testosterone-estrogen-binding globulin, Transcortin, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, androgen receptor splice variant 4b, erythroid derived 2, glucocorticoid nuclear receptor variant 1, like 2, nr3c1, nuclear factor erythroid 2 like 2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6, serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6

1 Images
Chemical Structure - Corticosterone, endogenous steroid hormone (AB143597)
  • Chemical Structure

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Chemical Structure - Corticosterone, endogenous steroid hormone (AB143597)

2D chemical structure image of ab143597, Corticosterone, endogenous steroid hormone

Key facts

CAS number

50-22-6

Purity

>98%

Form

Solid

form

Molecular weight

346.5 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>4</sub>

PubChem

5753

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 10 mM

Biochemical name

Corticosterone

Biological description

Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable.

Canonical smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O

Isomeric smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

InChi

InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChiKey

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

IUPAC Name

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Glucocorticoid Receptor (GR) Progesterone Receptor (PR) Mineralocorticoid Receptor (MR) Gli3 Androgen Receptor (AR) Nrf2 SHBG Cortisol Binding Globulin and SLC22A3/OCT3 are important molecular targets in various biological processes. The Glucocorticoid Receptor also known as NR3C1 has a molecular weight of approximately 97 kDa and is expressed in almost all cell types. GR acts as a transcription factor and regulates genes linked to inflammation immune response and metabolism. Progesterone Receptor and Androgen Receptor part of the steroid hormone receptor family are primarily expressed in reproductive tissues. Gli3 involved in limb and brain development acts as a transcriptional regulator. Nrf2 responsible for antioxidant responses binds to ARE in the DNA controlling detoxification genes. SHBG a glycoprotein of about 90 kDa is produced in the liver and transports sex steroids. Cortisol Binding Globulin with similar transport roles primarily binds cortisol in the bloodstream. SLC22A3/OCT3 is a transporter protein involved in organic cation uptake.
Biological function summary

These proteins are important for mediating responses to endogenous steroid hormones and other signaling molecules. GR PR and AR as part of steroid hormone receptor complexes influence gene transcription by directly interacting with DNA. Gli3 operates as part of the Hedgehog signaling pathway important for cellular differentiation. Nrf2 forms a complex with KEAP1 that regulates oxidative stress responses by modulating gene expression. SHBG and Cortisol Binding Globulin maintain the bioavailability of steroids in the circulatory system influencing their biological effects. SLC22A3/OCT3 is involved in neurotransmitter clearance influencing cellular uptake transportation processes.

Pathways

These proteins interact in diverse signaling cascades that influence cellular and systemic functions. GR and MR are critical components of the hypothalamic-pituitary-adrenal (HPA) axis tightly regulating cortisol metabolism including corticosterone function and solubility. Nrf2 is central to the NFE2L2 pathway mitigating oxidative damage by controlling antioxidant genes. PR and AR are key in reproductive hormone pathways that drive sexual differentiation and function often interacting with proteins like Estrogen Receptor. SLC22A3/OCT3 interfaces with monoamine neurotransmitter pathways relevant to neural function and behavior.

Aberrations in these targets are linked to a variety of conditions. Dysregulation of GR is associated with stress-related disorders such as Cushing's syndrome and Addison's disease which involve altered cortisol and corticosterone hormone dynamics. Nrf2's role in oxidative stress links it to neurodegenerative diseases like Parkinson's. AR mutations relate to prostate cancer with cross-talk between AR and proteins like FoxA1 exacerbating disease progression. Abnormalities in SHBG levels are implicated in metabolic syndrome impacting insulin sensitivity and glucocorticoid binding globulin levels can influence autoimmune conditions due to altered corticosteroid regulation.

Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Pharmacology research & perspectives 11:e01132 PubMed37740616

2023

Neuroprotective effect of Kurarinone against corticosterone-induced cytotoxicity on rat hippocampal neurons by targeting BACE1 to activate P13K-AKT signaling - A potential treatment in insomnia disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Guoqing Wu,Yanyan Wu

Biology 12: PubMed36829476

2023

Chronic Corticosterone Exposure Suppresses Copper Transport through GR-Mediated Intestinal CTR1 Pathway in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shihui Guo,Zijin Chen,Yingying Dong,Yingdong Ni,Ruqian Zhao,Wenqiang Ma

Frontiers in cell and developmental biology 10:731831 PubMed35478969

2022

Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Gao,Meiling Wu,Qiaohui Du,Jiagang Deng,Jiangang Shen

Frontiers in pharmacology 12:713715 PubMed34381366

2021

The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Zhang,Mengshi Yang,Qiongyu Yan,Xiaojian Xu,Fei Niu,Jinqian Dong,Yuan Zhuang,Shenghua Lu,Qianqian Ge,Baiyun Liu

Journal of neuroinflammation 17:318 PubMed33100225

2020

Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Zhang,Miao Bai,Xiaojian Xu,Mengshi Yang,Fei Niu,Fei Gao,Baiyun Liu

Journal of neurogastroenterology and motility 23:464-476 PubMed28343377

2017

Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach.

Applications

Unspecified application

Species

Rat

Meng Li,Lu Xue,Hong-Yan Zhu,Hongjun Wang,Xue Xu,Ping-An Zhang,Geping Wu,Guang-Yin Xu

Cell 160:745-758 PubMed25662011

2015

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel J Perry,João-Paulo G Camporez,Romy Kursawe,Paul M Titchenell,Dongyan Zhang,Curtis J Perry,Michael J Jurczak,Abulizi Abudukadier,Myoung Sook Han,Xian-Man Zhang,Hai-Bin Ruan,Xiaoyong Yang,Sonia Caprio,Susan M Kaech,Hei Sook Sul,Morris J Birnbaum,Roger J Davis,Gary W Cline,Kitt Falk Petersen,Gerald I Shulman
View all publications

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