Corticosterone, endogenous steroid hormone
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(7 Publications)
MW 346.5 Da, Purity >98%. Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable.
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ABP, ACLS, AIS, ANDR_HUMAN, AR, AR8, Aldosterone receptor, Androgen binding protein, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), CBG_HUMAN, Corticosteroid-binding globulin, DHTR, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), EMT, EMT organic cation transporter 3, EMTH, Extraneuronal monoamine transporter, GCCR, GCPS, GCRST, GCR_HUMAN, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GR, Glioma associated oncogene family zinc finger 3, Glucocorticoid receptor, Grl1, HUMARA, HYSP1, KD, Kennedy disease (KD), MCR_HUMAN, MGC133092, MLR, MR, Mineralocorticoid receptor, NF-E2-related factor 2, NF2L2_HUMAN, NR3 C2, NR3C2 protein, NR3C3, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 2, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Oct-03, Oncogene GLI3, Orct 3, Organic cation transporter 3, PAP A, PAPB, PGR, PPD IV, PR, PRA, PRB, PRGR_HUMAN, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, S22A3_HUMAN, SBMA, SBP, SHBG_HUMAN, SLC22 A3, SLC22A 3, SMAX1, Serpin A6, Sex hormone-binding globulin, Sex steroid-binding protein, Slc22a3, Solute carrier family 22 (extraneuronal monoamine transporter) member 3, Solute carrier family 22 (organic cation transporter) member 3, Solute carrier family 22 member 3, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TeBG, Testicular Feminization (TFM), Testis-specific androgen-binding protein, Testosterone binding beta globulin, Testosterone-estradiol-binding globulin, Testosterone-estrogen-binding globulin, Transcortin, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, androgen receptor splice variant 4b, erythroid derived 2, glucocorticoid nuclear receptor variant 1, like 2, nr3c1, nuclear factor erythroid 2 like 2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6, serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6
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Chemical Structure - Corticosterone, endogenous steroid hormone (AB143597)
2D chemical structure image of ab143597, Corticosterone, endogenous steroid hormone
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Supplementary information
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Biological function summary
These proteins are important for mediating responses to endogenous steroid hormones and other signaling molecules. GR PR and AR as part of steroid hormone receptor complexes influence gene transcription by directly interacting with DNA. Gli3 operates as part of the Hedgehog signaling pathway important for cellular differentiation. Nrf2 forms a complex with KEAP1 that regulates oxidative stress responses by modulating gene expression. SHBG and Cortisol Binding Globulin maintain the bioavailability of steroids in the circulatory system influencing their biological effects. SLC22A3/OCT3 is involved in neurotransmitter clearance influencing cellular uptake transportation processes.
Pathways
These proteins interact in diverse signaling cascades that influence cellular and systemic functions. GR and MR are critical components of the hypothalamic-pituitary-adrenal (HPA) axis tightly regulating cortisol metabolism including corticosterone function and solubility. Nrf2 is central to the NFE2L2 pathway mitigating oxidative damage by controlling antioxidant genes. PR and AR are key in reproductive hormone pathways that drive sexual differentiation and function often interacting with proteins like Estrogen Receptor. SLC22A3/OCT3 interfaces with monoamine neurotransmitter pathways relevant to neural function and behavior.
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Publications (7)
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Pharmacology research & perspectives 11:e01132 PubMed37740616
2023
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Biology 12: PubMed36829476
2023
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Frontiers in cell and developmental biology 10:731831 PubMed35478969
2022
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Frontiers in pharmacology 12:713715 PubMed34381366
2021
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Journal of neuroinflammation 17:318 PubMed33100225
2020
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Journal of neurogastroenterology and motility 23:464-476 PubMed28343377
2017
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Rat
Cell 160:745-758 PubMed25662011
2015
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