MW 293.79 Da, Purity >98%. Highly potent and selective 5-HT1B agonist (Ki = 2.0 nM compared to values of 89 (5-HT1A), 860 (5-HT1C), 49 (5-HT1D) and 1600 nM (5-HT2)). Shows many behavioural effects, reducing aggression and food intake. Additionally, enhances cocaine reinforcement.
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Key facts
- CAS number
- 131084-35-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 293.79 Da
- Molecular formula
- C15H20ClN3O
- PubChem identifier
- 11652258
- Nature
- Synthetic
Alternative names
5 HT1DB, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B, 5HT1B_HUMAN, HTR1D2, HTR1DB, Htr1b, Serotonin 1D beta receptor, Serotonin receptor 1B
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MW 293.79 Da, Purity >98%. Highly potent and selective 5-HT1B agonist (Ki = 2.0 nM compared to values of 89 (5-HT1A), 860 (5-HT1C), 49 (5-HT1D) and 1600 nM (5-HT2)). Shows many behavioural effects, reducing aggression and food intake. Additionally, enhances cocaine reinforcement.
Key facts
- CAS number
- 131084-35-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 293.79 Da
- Molecular formula
- C15H20ClN3O
- PubChem identifier
- 11652258
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- CP 94253 hydrochloride
- Biological description
Highly potent and selective 5-HT1B agonist (Ki = 2.0 nM compared to values of 89 (5-HT1A), 860 (5-HT1C), 49 (5-HT1D) and 1600 nM (5-HT2)). Shows many behavioural effects, reducing aggression and food intake. Additionally, enhances cocaine reinforcement.
- Canonical SMILES
- CCCOC1=NC2=C(C=C1)NC=C2C3=CCNCC3.Cl
- InChI
- InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
- InChIKey
- PIIOXKQIZCVXMD-UHFFFAOYSA-N
- IUPAC name
- 5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 5-HT1B receptor also known as the serotonin 1B receptor or HTR1B is a G protein-coupled receptor with a molecular mass of approximately 41 kDa. It binds serotonin an important neurotransmitter in the central nervous system. The 5-HT1B receptor is expressed in various brain regions including the striatum basal ganglia and frontal cortex. This receptor modulates neurotransmission by inhibiting the release of serotonin and other neurotransmitters like dopamine. Interruptions in its function can significantly affect synaptic plasticity and neuronal activity.
- Biological function summary
The 5-HT1B receptor plays a role in regulating aggressive behavior mood and appetite. It is part of a larger serotonin receptor family and works in conjunction with other receptor subtypes to maintain effective serotonergic signaling. By influencing dopamine and GABAergic systems the 5-HT1B receptor contributes to neural inhibition and the modulation of reward pathways. Alterations in its activity could influence emotional regulation and various behavioral responses.
- Pathways
The 5-HT1B receptor participates significantly in the serotonin signaling pathway and MAPK signaling pathway. Interacting with proteins such as G protein-coupled receptor kinases and beta-arrestins it influences downstream effects that include modulation of cAMP levels and changes in phosphatidylinositol turnover. Disturbances in these pathways can affect mood and behavior implicating the 5-HT1B receptor in various neurological pathways.
- Associated diseases and disorders
Irregular function of the 5-HT1B receptor links to conditions such as depression and migraine. This receptor through its role in mood regulation implicates it in mood disorders if dysregulated. It also connects to genetic factors influencing migraine possibly through interactions with proteins like calcitonin gene-related peptide (CGRP). Despite the complexity of these conditions the 5-HT1B receptor is a potential target for therapeutic interventions suggesting its importance in disease mechanisms.
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1 product image
Chemical Structure - CP 94253 dihydrochloride, 5-HT1B agonist (ab120522)
2D chemical structure image of ab120522, CP 94253 dihydrochloride, 5-HT1B agonist
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