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AB120060

CPCCOEt, mGlu1 antagonist

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(16 Publications)

MW 247.25 Da, Purity >98%. Potent, selective non-competitive mGlu1 metabotropic glutamate receptor antagonist (IC50 = 6.5 μM at hmGluR1 with no activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM).

View Alternative Names

GLUR, GPRC1A, GRM1-Alpha, GRM1_HUMAN, Glutamate receptor metabotropic 1, MGLU1, Metabotropic glutamate receptor 1, SCAR13, Smp_128940, mGluR1

1 Images
Chemical Structure - CPCCOEt, mGlu1 antagonist (AB120060)
  • Chemical Structure

Lab

Chemical Structure - CPCCOEt, mGlu1 antagonist (AB120060)

2D chemical structure image of ab120060, CPCCOEt, mGlu1 antagonist

Key facts

CAS number

179067-99-3

Purity

>98%

Form

Solid

form

Molecular weight

247.25 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>3</sub>NO<sub>4</sub>

PubChem

6278000

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 5 mM

Biochemical name

CPCCOEt

Biological description

Potent, selective non-competitive mGlu1 metabotropic glutamate receptor antagonist (IC50 = 6.5 μM at hmGluR1 with no activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM).

Canonical smiles

CCOC(=O)C12CC1C(=NO)C3=CC=CC=C3O2

Isomeric smiles

CCOC(=O)C12CC1/C(=N\O)/C3=CC=CC=C3O2

InChi

InChI=1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-

InChiKey

FXCTZFMSAHZQTR-KAMYIIQDSA-N

IUPAC Name

ethyl (7E)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate

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Complementary Products

Biochemicals

AB120008

MPEP hydrochloride, mGlu5 antagonist

Functional Studies - MPEP hydrochloride, mGlu5 antagonist (AB120008)

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Biochemicals

AB120046

NBQX disodium salt, AMPA / kainate antagonist

Chemical Structure - NBQX disodium salt, AMPA / kainate antagonist (AB120046)

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Primary Antibodies

AB88877

Anti-Norbin antibody

Western blot - Anti-Norbin antibody (AB88877)

  • 4
  • 1
Primary Antibodies

AB190368

Anti-Aldolase C antibody [4A9] - N-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Aldolase C antibody [4A9] - N-terminal (AB190368)

  • 4
  • 1
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed39147589

2024

Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.

Applications

Unspecified application

Species

Unspecified reactive species

Riya Elizabeth Thomas,Franziska Mudlaff,Kyra Schweers,William Todd Farmer,Aparna Suvrathan

Scientific reports 7:44817 PubMed28322255

2017

Ca-permeable AMPA receptors in mouse olfactory bulb astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Damian Droste,Gerald Seifert,Laura Seddar,Oliver Jädtke,Christian Steinhäuser,Christian Lohr

Journal of neurophysiology 113:3634-45 PubMed25855696

2015

Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Matthew A Xu-Friedman

Molecular psychiatry 20:959-73 PubMed25266126

2014

Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

A Ledonne,A Nobili,E C Latagliata,V Cavallucci,E Guatteo,S Puglisi-Allegra,M D'Amelio,N B Mercuri

Journal of neurophysiology 110:505-21 PubMed23636718

2013

Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Gang Liu,Sukjae Joshua Kang,Tian-Yao Shi,Kohei Koga,Ming-Ming Zhang,Graham L Collingridge,Bong-Kiun Kaang,Min Zhuo

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:8722-9 PubMed21677156

2011

Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Marion Najac,Didier De Saint Jan,Leire Reguero,Pedro Grandes,Serge Charpak

Proceedings of the National Academy of Sciences of 108:9993-7 PubMed21628565

2011

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Jeanne Ster,José María Mateos,Benjamin Friedrich Grewe,Guyllaume Coiret,Corrado Corti,Mauro Corsi,Fritjof Helmchen,Urs Gerber

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:7450-5 PubMed21593328

2011

Excitatory modulation in the cochlear nucleus through group I metabotropic glutamate receptor activation.

Applications

Unspecified application

Species

Unspecified reactive species

Soham Chanda,Matthew A Xu-Friedman

The Journal of physiology 589:1927-41 PubMed21486802

2011

Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Borisovska,Matthew J McGinley,AeSoon Bensen,Gary L Westbrook

British journal of pharmacology 162:974-88 PubMed21054344

2010

Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Flora E Kovacs,Peter Illes,Bela Szabo
View all publications
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