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AB145275

CPM, Thiol-reactive fluorescent probe

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(1 Publication)

MW 402.44 g/mol, Purity >95%. Widely used blue fluorescent thiol-reactive dye. Essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.
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Chemical Structure - CPM, Thiol-reactive fluorescent probe (AB145275)
  • Chemical Structure

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Chemical Structure - CPM, Thiol-reactive fluorescent probe (AB145275)

2D chemical structure image of ab145275, CPM, Thiol-reactive fluorescent probe

Key facts

CAS number

76877-33-3

Purity

>95%

Molecular weight

402.44 g/mol

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO

Biological description

Widely used blue fluorescent thiol-reactive dye. Essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.

InChi

InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChiKey

YGIABALXNBVHBX-UHFFFAOYSA-N

IUPAC Name

7-Diethylamino-3-(4-maleimidylphenyl)-4-methylcoumarin

Excitation/Emission

Ex: 391nm, Em: 472nm

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4187 PubMed40328741

2025

A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Suman Pokhrel,Gwangbeom Heo,Irimpan Mathews,Shun Yokoi,Tsutomu Matsui,Ayori Mitsutake,Soichi Wakatsuki,Daria Mochly-Rosen
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